STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANXA9Annexin. (345 aa)    
Predicted Functional Partners:
CD63
Tetraspanin.
   
  
 0.671
CASP3
Caspase-3 isoform X1; Belongs to the peptidase C14A family.
   
 
 0.647
TSG101
Tumor susceptibility gene 101 protein isoform X1.
   
 
 0.633
BCL2
Apoptosis regulator Bcl-2.
   
  
 0.616
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.586
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.542
SERPINA6
Corticosteroid-binding globulin; Belongs to the serpin family.
   
 0.538
CASP8
Caspase-8 isoform X1; Belongs to the peptidase C14A family.
   
 
 0.537
ALB
Serum albumin.
   
  
 0.533
ATP6V1C2
V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
   
  
 0.533
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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