HSH2D protein (Odobenus rosmarus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

HSH2D

Hematopoietic SH2 domain-containing protein. (360 aa)

Predicted Functional Partners:

LOC101380319

0.548

SPAG5

0.527

PKMYT1

0.527

BCL7C

0.523

KIFC1

0.523

TXK

0.514

CACNA2D4

0.472

RECQL

0.470

CENPN

0.451

TMEM140

0.451

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL7C	HSH2D	A0A2U3VQ39	A0A2U3W8P2	B-cell CLL/lymphoma 7 protein family member C isoform X1.	Hematopoietic SH2 domain-containing protein.	0.523
CACNA2D4	HSH2D	A0A2U3WEF6	A0A2U3W8P2	Voltage-dependent calcium channel subunit alpha-2/delta-4.	Hematopoietic SH2 domain-containing protein.	0.472
CENPN	HSH2D	A0A2U3VC53	A0A2U3W8P2	Centromere protein N isoform X1.	Hematopoietic SH2 domain-containing protein.	0.451
CENPN	KIFC1	A0A2U3VC53	A0A2U3WGF7	Centromere protein N isoform X1.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.538
CENPN	PKMYT1	A0A2U3VC53	A0A2U3W595	Centromere protein N isoform X1.	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2; Belongs to the protein kinase superfamily.	0.482
CENPN	SPAG5	A0A2U3VC53	A0A2U3VWF2	Centromere protein N isoform X1.	Sperm-associated antigen 5.	0.685
HSH2D	BCL7C	A0A2U3W8P2	A0A2U3VQ39	Hematopoietic SH2 domain-containing protein.	B-cell CLL/lymphoma 7 protein family member C isoform X1.	0.523
HSH2D	CACNA2D4	A0A2U3W8P2	A0A2U3WEF6	Hematopoietic SH2 domain-containing protein.	Voltage-dependent calcium channel subunit alpha-2/delta-4.	0.472
HSH2D	CENPN	A0A2U3W8P2	A0A2U3VC53	Hematopoietic SH2 domain-containing protein.	Centromere protein N isoform X1.	0.451
HSH2D	KIFC1	A0A2U3W8P2	A0A2U3WGF7	Hematopoietic SH2 domain-containing protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.523
HSH2D	LOC101380319	A0A2U3W8P2	A0A2U3WA73	Hematopoietic SH2 domain-containing protein.	LOW QUALITY PROTEIN: GRB2-related adapter protein.	0.548
HSH2D	PKMYT1	A0A2U3W8P2	A0A2U3W595	Hematopoietic SH2 domain-containing protein.	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2; Belongs to the protein kinase superfamily.	0.527
HSH2D	RECQL	A0A2U3W8P2	A0A2U3ZKU1	Hematopoietic SH2 domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.470
HSH2D	SPAG5	A0A2U3W8P2	A0A2U3VWF2	Hematopoietic SH2 domain-containing protein.	Sperm-associated antigen 5.	0.527
HSH2D	TMEM140	A0A2U3W8P2	A0A2U3WD41	Hematopoietic SH2 domain-containing protein.	Transmembrane protein 140.	0.451
HSH2D	TXK	A0A2U3W8P2	A0A2U3VMR9	Hematopoietic SH2 domain-containing protein.	Tyrosine-protein kinase.	0.514
KIFC1	CENPN	A0A2U3WGF7	A0A2U3VC53	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Centromere protein N isoform X1.	0.538
KIFC1	HSH2D	A0A2U3WGF7	A0A2U3W8P2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Hematopoietic SH2 domain-containing protein.	0.523
KIFC1	PKMYT1	A0A2U3WGF7	A0A2U3W595	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2; Belongs to the protein kinase superfamily.	0.722
KIFC1	SPAG5	A0A2U3WGF7	A0A2U3VWF2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Sperm-associated antigen 5.	0.950

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Network Stats

number of nodes:

8

number of edges:

13

average node degree:

3.25

avg. local clustering coefficient:

0.786

expected number of edges:

7

PPI enrichment p-value:

0.0297

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006310

DNA recombination

5 of 43

1.67

2.08

2.13e-05

GO:0015074

DNA integration

3 of 8

2.17

1.87

0.00053

GO:0006259

DNA metabolic process

7 of 120

1.37

1.84

1.31e-06

GO:0006313

Transposition, DNA-mediated

3 of 10

2.08

1.8

0.00062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004803

Transposase activity

3 of 10

2.08

1.79

0.00065

GO:0140097

Catalytic activity, acting on DNA

5 of 74

1.43

1.45

0.00029

GO:0003676

Nucleic acid binding

7 of 345

0.91

0.79

0.00045

GO:0003677

DNA binding

5 of 204

0.99

0.72

0.0073

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5256

DNA integration, and AAA domain

5 of 5

2.6

4.84

3.45e-09

CL:5131

Mostly uncharacterized, incl. Protein transmembrane transport, and Lipid degradation

6 of 98

1.39

1.79

4.65e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13276

HTH-like domain

2 of 2

2.6

1.13

0.0139

PF01527

Transposase

2 of 2

2.6

1.13

0.0139

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01477

DDE transposase retroviral integrase sub-family

2 of 2

2.6

1.53

0.0029

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