STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101381577E3 ubiquitin-protein ligase HERC2. (4837 aa)    
Predicted Functional Partners:
PIAS4
E3 SUMO-protein ligase PIAS4.
    
 0.934
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.905
NEURL4
Neuralized-like protein 4 isoform X1.
    
 
 0.785
USP32
Ubiquitin carboxyl-terminal hydrolase 32; Belongs to the peptidase C19 family.
   
 
 0.759
MAPK6
Mitogen-activated protein kinase 6.
    
 0.759
RNF138
E3 ubiquitin-protein ligase RNF138 isoform X1.
      
 0.754
DOCK10
Dedicator of cytokinesis protein 10 isoform X1; Belongs to the DOCK family.
    
  0.731
HUWE1
E3 ubiquitin-protein ligase HUWE1 isoform X1.
   
0.728
LOC101382809
E3 ubiquitin-protein ligase TRIM36.
      
 0.726
RMND5A
Protein RMD5 homolog A.
      
 0.702
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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