KLHL42 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

KLHL42

LOW QUALITY PROTEIN: kelch-like protein 42. (752 aa)

Predicted Functional Partners:

CUL3

0.751

NUP37

0.730

CCDC91

0.724

CCDC53

0.723

DDX11

0.631

CUL1

0.594

UBE2M

0.542

ASB6

0.526

TMEM251

0.522

RNF34

0.512

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASB6	KLHL42	A0A2U3VD53	A0A2U3WAH4	Ankyrin repeat and SOCS box protein 6 isoform X1.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.526
ASB6	RNF34	A0A2U3VD53	A0A2U3VLS6	Ankyrin repeat and SOCS box protein 6 isoform X1.	E3 ubiquitin-protein ligase RNF34 isoform X1.	0.441
CCDC53	CCDC91	A0A2U3WUW3	A0A2U3WAG9	WASH complex subunit CCDC53 isoform X1.	Coiled-coil domain-containing protein 91 isoform X1.	0.723
CCDC53	DDX11	A0A2U3WUW3	A0A2U3ZSE8	WASH complex subunit CCDC53 isoform X1.	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	0.523
CCDC53	KLHL42	A0A2U3WUW3	A0A2U3WAH4	WASH complex subunit CCDC53 isoform X1.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.723
CCDC53	NUP37	A0A2U3WUW3	A0A2U3WUV0	WASH complex subunit CCDC53 isoform X1.	Nucleoporin Nup37 isoform X1.	0.896
CCDC91	CCDC53	A0A2U3WAG9	A0A2U3WUW3	Coiled-coil domain-containing protein 91 isoform X1.	WASH complex subunit CCDC53 isoform X1.	0.723
CCDC91	DDX11	A0A2U3WAG9	A0A2U3ZSE8	Coiled-coil domain-containing protein 91 isoform X1.	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	0.643
CCDC91	KLHL42	A0A2U3WAG9	A0A2U3WAH4	Coiled-coil domain-containing protein 91 isoform X1.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.724
CCDC91	NUP37	A0A2U3WAG9	A0A2U3WUV0	Coiled-coil domain-containing protein 91 isoform X1.	Nucleoporin Nup37 isoform X1.	0.742
CUL1	CUL3	A0A2U3WJA3	A0A2U3WFR0	Cullin-1; Belongs to the cullin family.	Cullin-3 isoform X1; Belongs to the cullin family.	0.764
CUL1	KLHL42	A0A2U3WJA3	A0A2U3WAH4	Cullin-1; Belongs to the cullin family.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.594
CUL1	UBE2M	A0A2U3WJA3	A0A2U3WBF1	Cullin-1; Belongs to the cullin family.	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.	0.981
CUL3	CUL1	A0A2U3WFR0	A0A2U3WJA3	Cullin-3 isoform X1; Belongs to the cullin family.	Cullin-1; Belongs to the cullin family.	0.764
CUL3	KLHL42	A0A2U3WFR0	A0A2U3WAH4	Cullin-3 isoform X1; Belongs to the cullin family.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.751
CUL3	UBE2M	A0A2U3WFR0	A0A2U3WBF1	Cullin-3 isoform X1; Belongs to the cullin family.	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.	0.844
DDX11	CCDC53	A0A2U3ZSE8	A0A2U3WUW3	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	WASH complex subunit CCDC53 isoform X1.	0.523
DDX11	CCDC91	A0A2U3ZSE8	A0A2U3WAG9	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	Coiled-coil domain-containing protein 91 isoform X1.	0.643
DDX11	KLHL42	A0A2U3ZSE8	A0A2U3WAH4	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	LOW QUALITY PROTEIN: kelch-like protein 42.	0.631
DDX11	NUP37	A0A2U3ZSE8	A0A2U3WUV0	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11.	Nucleoporin Nup37 isoform X1.	0.513

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.941

expected number of edges:

16

PPI enrichment p-value:

2.03e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

9 of 236

1.01

1.17

2.57e-07

GO:0044271

Cellular nitrogen compound biosynthetic process

9 of 327

0.86

0.88

3.63e-06

GO:1901566

Organonitrogen compound biosynthetic process

9 of 407

0.77

0.72

2.10e-05

GO:0006139

Nucleobase-containing compound metabolic process

9 of 537

0.65

0.55

0.00022

GO:0034641

Cellular nitrogen compound metabolic process

10 of 707

0.57

0.49

0.00014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

8 of 9

2.37

6.45

1.76e-14

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 3

2.25

1.23

0.0050

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

8 of 9

2.37

6.71

3.72e-15

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 6

2.34

4.18

3.68e-09

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 3

2.42

2.56

1.40e-05

GO:0005886

Plasma membrane

8 of 491

0.64

0.51

0.00095

GO:0005622

Intracellular anatomical structure

10 of 1040

0.41

0.33

0.0029

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22479625

(2012) Comparative analysis of gene content evolution in phytoplasmas and mycoplasmas.

4 of 102

1.02

0.56

0.0355

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:249

ATP synthesis

8 of 8

2.42

6.65

1.05e-14

CL:84

Ribosome, and Ribonucleoside triphosphate biosynthetic process

10 of 91

1.46

2.77

5.39e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pth00190

Oxidative phosphorylation

9 of 19

2.1

6.04

8.55e-16

pth01100

Metabolic pathways

8 of 503

0.63

0.47

0.0041

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

8 of 10

2.33

6.39

1.27e-14

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.42

4.26

3.81e-09

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 5

2.2

2.13

7.39e-05

GOCC:0032991

Protein-containing complex

9 of 435

0.74

0.67

6.39e-05

GOCC:0005622

Intracellular

10 of 995

0.43

0.34

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 8

2.42

6.87

3.09e-15

KW-0066

ATP synthesis

8 of 8

2.42

6.87

3.09e-15

KW-0139

CF(1)

5 of 5

2.42

4.29

3.15e-09

KW-0138

CF(0)

3 of 3

2.42

2.46

2.19e-05

KW-1003

Cell membrane

8 of 110

1.29

1.85

2.66e-08

(more ...)

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