UBE2B protein (Odobenus rosmarus) - STRING interaction network

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Predicted Interactions

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Score

UBE2B

Ubiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)

Predicted Functional Partners:

RAD18

0.908

LOC101366786

0.900

LOC101364011

0.845

UBE2V1

0.845

RPS27A

0.808

RNF40

0.804

RNF20

0.803

PCNA

0.747

TRIP12

0.717

UBA52

0.716

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101364011	LOC101366786	A0A2U3W734	A0A2U3W424	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.845
LOC101364011	PCNA	A0A2U3W734	A0A2U3VSK6	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.610
LOC101364011	RAD18	A0A2U3W734	A0A2U3VE84	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	E3 ubiquitin-protein ligase RAD18 isoform X1.	0.598
LOC101364011	RPS27A	A0A2U3W734	A0A2U3W6C1	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	ubiquitin-40S ribosomal protein S27a.	0.997
LOC101364011	UBA52	A0A2U3W734	A0A2U3ZJX2	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	ubiquitin-60S ribosomal protein L40 isoform X1.	0.996
LOC101364011	UBE2B	A0A2U3W734	A0A2U3WAV2	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	Ubiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.845
LOC101364011	UBE2V1	A0A2U3W734	A0A2U3WT75	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	Ubiquitin-conjugating enzyme E2 variant 1 isoform X1.	0.813
LOC101366786	LOC101364011	A0A2U3W424	A0A2U3W734	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	0.845
LOC101366786	PCNA	A0A2U3W424	A0A2U3VSK6	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.747
LOC101366786	RAD18	A0A2U3W424	A0A2U3VE84	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RAD18 isoform X1.	0.908
LOC101366786	RNF20	A0A2U3W424	A0A2U3WXL0	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.803
LOC101366786	RNF40	A0A2U3W424	A0A2U3VQ53	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.804
LOC101366786	RPS27A	A0A2U3W424	A0A2U3W6C1	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	ubiquitin-40S ribosomal protein S27a.	0.808
LOC101366786	TRIP12	A0A2U3W424	A0A2U3VM55	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase TRIP12 isoform X1.	0.717
LOC101366786	UBA52	A0A2U3W424	A0A2U3ZJX2	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	ubiquitin-60S ribosomal protein L40 isoform X1.	0.716
LOC101366786	UBE2B	A0A2U3W424	A0A2U3WAV2	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC101366786	UBE2V1	A0A2U3W424	A0A2U3WT75	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 1 isoform X1.	0.845
PCNA	LOC101364011	A0A2U3VSK6	A0A2U3W734	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.	0.610
PCNA	LOC101366786	A0A2U3VSK6	A0A2U3W424	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.747
PCNA	RAD18	A0A2U3VSK6	A0A2U3VE84	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	E3 ubiquitin-protein ligase RAD18 isoform X1.	0.983

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.866

expected number of edges:

14

PPI enrichment p-value:

1.64e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 43

2.41

4.56

7.38e-10

GO:0006264

Mitochondrial DNA replication

3 of 11

2.7

2.38

4.02e-05

GO:0106074

aminoacyl-tRNA metabolism involved in translational fidelity

3 of 13

2.63

2.3

5.61e-05

GO:0006419

alanyl-tRNA aminoacylation

2 of 2

3.26

1.79

0.00059

GO:0009059

Macromolecule biosynthetic process

9 of 1607

1.01

1.08

9.67e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 45

2.39

4.87

1.31e-10

GO:0140640

Catalytic activity, acting on a nucleic acid

10 of 542

1.53

2.99

6.88e-12

GO:0140098

Catalytic activity, acting on RNA

7 of 336

1.58

2.47

7.14e-08

GO:0002161

aminoacyl-tRNA editing activity

3 of 15

2.56

2.35

4.18e-05

GO:0000049

tRNA binding

4 of 94

1.89

1.99

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 12

2.66

2.21

8.39e-05

GO:0005760

Gamma DNA polymerase complex

2 of 3

3.09

1.64

0.0011

GO:0042645

Mitochondrial nucleoid

3 of 40

2.14

1.54

0.0011

GO:0005739

Mitochondrion

7 of 1640

0.89

0.71

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31610802

(2019) Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia.

4 of 17

2.64

2.58

1.63e-05

PMID:29579307

(2018) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

3 of 11

2.7

1.58

0.0013

PMID:26109058

(2015) Nuclear respiratory factor 2 induces SIRT3 expression.

3 of 20

2.44

1.33

0.0035

PMID:22386318

(2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.

3 of 19

2.46

1.33

0.0035

PMID:37148543

(2023) Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.

3 of 23

2.38

1.32

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1857

Aminoacyl-tRNA biosynthesis

6 of 30

2.56

5.3

4.26e-11

CL:1863

aminoacyl-tRNA synthetase multienzyme complex

4 of 5

3.17

4.61

3.85e-09

CL:2589

Mitochondrial transcription, and Gamma DNA polymerase complex

4 of 11

2.82

4.03

3.24e-08

CL:1899

alanyl-tRNA aminoacylation, and threonyl-tRNA aminoacylation

2 of 5

2.87

1.49

0.0020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00970

Aminoacyl-tRNA biosynthesis

6 of 36

2.49

5.53

8.44e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 13

2.75

3.59

2.06e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 18

2.71

5.07

2.27e-10

KW-0648

Protein biosynthesis

5 of 75

2.09

3.4

5.33e-08

KW-0820

tRNA-binding

3 of 10

2.74

2.95

3.52e-06

KW-0067

ATP-binding

5 of 770

1.08

0.84

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01411

tRNA synthetases class II (A)

2 of 3

3.09

1.22

0.0062

PF09334

tRNA synthetases class I (M)

2 of 8

2.66

1.02

0.0139

PF03129

Anticodon binding domain

2 of 10

2.56

1.02

0.0139

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00991

A conserved domain of 46 amino acids, called WHEP-TRS has been shown PUBMED:1756734 to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in ...

2 of 6

2.79

1.22

0.0061

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 6

2.79

1.22

0.0061

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