STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BRCA2Breast cancer type 2 susceptibility protein. (3150 aa)    
Predicted Functional Partners:
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 0.997
PALB2
Partner and localizer of BRCA2.
   
 0.996
FANCD2
Fanconi anemia group D2 protein.
   
 0.987
RAD51C
DNA repair protein RAD51 homolog 3 isoform X1.
   
 0.985
SHFM1
26S proteasome complex subunit DSS1.
    
 0.978
BRIP1
Fanconi anemia group J protein.
   
 0.955
BRCA1
Breast cancer type 1 susceptibility protein isoform X1.
   
 0.946
LOC101367731
Breast cancer type 2 susceptibility protein homolog.
 
     0.943
BARD1
BRCA1-associated RING domain protein 1 isoform X1.
   
 0.921
SYCP3
Synaptonemal complex protein 3 isoform X1.
    
 0.912
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.