ICOS protein (Odobenus rosmarus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ICOS

Inducible T-cell costimulator. (209 aa)

Predicted Functional Partners:

ICOSLG

0.999

CD40LG

0.991

PIK3R1

0.964

PIK3R3

0.956

PIK3R2

0.956

PIK3CA

0.949

BCL6

0.947

PIK3CD

0.937

PIK3CB

0.932

IL21R

0.898

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CD40LG	A0A2U3WVI0	A0A2U3WNH1	B-cell lymphoma 6 protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.798
BCL6	ICOS	A0A2U3WVI0	A0A2U3WFU9	B-cell lymphoma 6 protein.	Inducible T-cell costimulator.	0.947
BCL6	IL21R	A0A2U3WVI0	A0A2U3VQ60	B-cell lymphoma 6 protein.	Interleukin-21 receptor.	0.859
CD40LG	BCL6	A0A2U3WNH1	A0A2U3WVI0	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	B-cell lymphoma 6 protein.	0.798
CD40LG	ICOS	A0A2U3WNH1	A0A2U3WFU9	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Inducible T-cell costimulator.	0.991
CD40LG	ICOSLG	A0A2U3WNH1	A0A2U3ZR14	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	LOW QUALITY PROTEIN: ICOS ligand.	0.449
CD40LG	IL21R	A0A2U3WNH1	A0A2U3VQ60	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-21 receptor.	0.712
ICOS	BCL6	A0A2U3WFU9	A0A2U3WVI0	Inducible T-cell costimulator.	B-cell lymphoma 6 protein.	0.947
ICOS	CD40LG	A0A2U3WFU9	A0A2U3WNH1	Inducible T-cell costimulator.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.991
ICOS	ICOSLG	A0A2U3WFU9	A0A2U3ZR14	Inducible T-cell costimulator.	LOW QUALITY PROTEIN: ICOS ligand.	0.999
ICOS	IL21R	A0A2U3WFU9	A0A2U3VQ60	Inducible T-cell costimulator.	Interleukin-21 receptor.	0.898
ICOS	PIK3CA	A0A2U3WFU9	A0A2U3VSW6	Inducible T-cell costimulator.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
ICOS	PIK3CB	A0A2U3WFU9	A0A2U3WV15	Inducible T-cell costimulator.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.932
ICOS	PIK3CD	A0A2U3WFU9	A0A2U3VQZ1	Inducible T-cell costimulator.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.937
ICOS	PIK3R1	A0A2U3WFU9	A0A2U3X1Z3	Inducible T-cell costimulator.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.964
ICOS	PIK3R2	A0A2U3WFU9	A0A2U3W8T2	Inducible T-cell costimulator.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.956
ICOS	PIK3R3	A0A2U3WFU9	A0A2U3VYN3	Inducible T-cell costimulator.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.956
ICOSLG	CD40LG	A0A2U3ZR14	A0A2U3WNH1	LOW QUALITY PROTEIN: ICOS ligand.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.449
ICOSLG	ICOS	A0A2U3ZR14	A0A2U3WFU9	LOW QUALITY PROTEIN: ICOS ligand.	Inducible T-cell costimulator.	0.999
ICOSLG	PIK3R1	A0A2U3ZR14	A0A2U3X1Z3	LOW QUALITY PROTEIN: ICOS ligand.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.454