RIPK1 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RIPK1

Receptor-interacting serine/threonine-protein kinase 1. (665 aa)

Predicted Functional Partners:

CASP8

0.999

FADD

0.999

RIPK3

0.999

TRADD

0.999

TRAF2

0.998

TAB2

0.997

TNFRSF1A

0.997

IKBKG

0.997

CYLD

0.990

TAB3

0.986

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	CYLD	A0A2U3VG28	A0A2U3WIE3	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	0.948
CASP8	FADD	A0A2U3VG28	A0A2U3VH33	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	IKBKG	A0A2U3VG28	A0A2U3ZV61	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	NF-kappa-B essential modulator isoform X1.	0.896
CASP8	RIPK1	A0A2U3VG28	A0A2U3WI77	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1.	0.999
CASP8	RIPK3	A0A2U3VG28	A0A2U3W2H2	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.	0.998
CASP8	TNFRSF1A	A0A2U3VG28	A0A2U3WWL7	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 1A.	0.595
CASP8	TRADD	A0A2U3VG28	A0A2U3ZRF9	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1.	0.998
CASP8	TRAF2	A0A2U3VG28	A0A2U3WTY7	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.893
CYLD	CASP8	A0A2U3WIE3	A0A2U3VG28	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.948
CYLD	FADD	A0A2U3WIE3	A0A2U3VH33	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.811
CYLD	IKBKG	A0A2U3WIE3	A0A2U3ZV61	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	NF-kappa-B essential modulator isoform X1.	0.966
CYLD	RIPK1	A0A2U3WIE3	A0A2U3WI77	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Receptor-interacting serine/threonine-protein kinase 1.	0.990
CYLD	RIPK3	A0A2U3WIE3	A0A2U3W2H2	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.	0.687
CYLD	TAB2	A0A2U3WIE3	A0A2U3W7D4	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.760
CYLD	TAB3	A0A2U3WIE3	A0A2U3X2S8	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3.	0.722
CYLD	TNFRSF1A	A0A2U3WIE3	A0A2U3WWL7	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor superfamily member 1A.	0.963
CYLD	TRADD	A0A2U3WIE3	A0A2U3ZRF9	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1.	0.832
CYLD	TRAF2	A0A2U3WIE3	A0A2U3WTY7	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.972
FADD	CASP8	A0A2U3VH33	A0A2U3VG28	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.999
FADD	CYLD	A0A2U3VH33	A0A2U3WIE3	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	0.811