STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CMTR1Cap-specific mRNA (Nucleoside-2'-O-)-methyltransferase 1. (835 aa)    
Predicted Functional Partners:
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
 
      0.846
LOC101363249
Tripartite motif-containing protein 34.
   
 
 0.792
CCDC115
Coiled-coil domain-containing protein 115.
      
 0.721
WDR7
WD repeat-containing protein 7 isoform X1.
      
 0.694
SLC35A1
CMP-sialic acid transporter isoform X1.
   
  
 0.680
SRRM4
Serine/arginine repetitive matrix protein 4.
      
 0.668
DHX15
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15.
   
 
 0.595
POLG
DNA polymerase subunit gamma-1.
   
    0.579
AMBRA1
Activating molecule in BECN1-regulated autophagy protein 1 isoform X1.
   
    0.577
PHF8
Histone lysine demethylase PHF8 isoform X1.
   
    0.570
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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