DSG1 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DSG1

Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1060 aa)

Predicted Functional Partners:

PKP1

0.829

CDSN

0.818

JUP

0.814

CASP3

0.787

PERP

0.776

PKP2

0.705

PKP3

0.697

DSC2

0.678

DSC1

0.678

DSC3

0.678

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	DSG1	A0A2U3ZTA6	A0A2U3WU90	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.787
CASP3	JUP	A0A2U3ZTA6	A0A2U3WNC2	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Junction plakoglobin.	0.419
CASP3	PKP1	A0A2U3ZTA6	A0A2U3VEA2	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Plakophilin-1.	0.767
CDSN	DSC1	A0A2U3WJT0	A0A2U3WUJ7	Corneodesmosin.	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.572
CDSN	DSC2	A0A2U3WJT0	A0A2U3WU99	Corneodesmosin.	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.751
CDSN	DSC3	A0A2U3WJT0	A0A2U3WUK1	Corneodesmosin.	Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.651
CDSN	DSG1	A0A2U3WJT0	A0A2U3WU90	Corneodesmosin.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.818
CDSN	PKP1	A0A2U3WJT0	A0A2U3VEA2	Corneodesmosin.	Plakophilin-1.	0.428
DSC1	CDSN	A0A2U3WUJ7	A0A2U3WJT0	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Corneodesmosin.	0.572
DSC1	DSG1	A0A2U3WUJ7	A0A2U3WU90	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.678
DSC1	JUP	A0A2U3WUJ7	A0A2U3WNC2	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin.	0.862
DSC1	PERP	A0A2U3WUJ7	A0A2U3WMS0	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	P53 apoptosis effector related to PMP-22.	0.588
DSC1	PKP1	A0A2U3WUJ7	A0A2U3VEA2	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-1.	0.627
DSC1	PKP2	A0A2U3WUJ7	A0A2U3WFW4	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-2.	0.750
DSC1	PKP3	A0A2U3WUJ7	A0A2U3W6J5	Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-3.	0.737
DSC2	CDSN	A0A2U3WU99	A0A2U3WJT0	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Corneodesmosin.	0.751
DSC2	DSG1	A0A2U3WU99	A0A2U3WU90	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.678
DSC2	JUP	A0A2U3WU99	A0A2U3WNC2	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin.	0.895
DSC2	PERP	A0A2U3WU99	A0A2U3WMS0	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	P53 apoptosis effector related to PMP-22.	0.590
DSC2	PKP1	A0A2U3WU99	A0A2U3VEA2	Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-1.	0.627

page 1 of 5

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About