STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101370081S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)    
Predicted Functional Partners:
LOC101386739
UPF0536 protein C12orf66 homolog isoform X1.
    
 0.836
DEPDC5
DEP domain-containing protein 5.
    
 0.836
ITFG2
Integrin-alpha FG-GAP repeat-containing protein 2 isoform X1.
    
 0.794
KPTN
Kaptin isoform X2.
    
 0.782
SZT2
Protein SZT2.
    
 0.756
SLC39A9
Zinc transporter ZIP9 isoform X1.
      
 0.735
NPRL3
Nitrogen permease regulator 3-like protein isoform X1.
   
 0.720
SIAE
Sialate O-acetylesterase.
      
 0.706
NPRL2
Nitrogen permease regulator 2-like protein.
    
 0.703
MLST8
Target of rapamycin complex subunit LST8.
     
 0.684
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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