node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF1 | GRB2 | A0A2U3WF20 | A0A2U3VHU3 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Growth factor receptor-bound protein 2 isoform X1. | 0.505 |
CSF1 | KIT | A0A2U3WF20 | A0A2U3ZCP5 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.959 |
CSF1 | KITLG | A0A2U3WF20 | A0A2U3WZ03 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.451 |
CSF1 | STAT3 | A0A2U3WF20 | A0A2U3WNF0 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Signal transducer and activator of transcription. | 0.544 |
GRB2 | CSF1 | A0A2U3VHU3 | A0A2U3WF20 | Growth factor receptor-bound protein 2 isoform X1. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.505 |
GRB2 | KIT | A0A2U3VHU3 | A0A2U3ZCP5 | Growth factor receptor-bound protein 2 isoform X1. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.984 |
GRB2 | KITLG | A0A2U3VHU3 | A0A2U3WZ03 | Growth factor receptor-bound protein 2 isoform X1. | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.504 |
GRB2 | LOC101374328 | A0A2U3VHU3 | A0A2U3ZMT2 | Growth factor receptor-bound protein 2 isoform X1. | Tyrosine-protein phosphatase non-receptor type 11-like. | 0.994 |
GRB2 | PIK3CA | A0A2U3VHU3 | A0A2U3VSW6 | Growth factor receptor-bound protein 2 isoform X1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.691 |
GRB2 | PIK3R1 | A0A2U3VHU3 | A0A2U3X1Z3 | Growth factor receptor-bound protein 2 isoform X1. | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. | 0.951 |
GRB2 | PIK3R2 | A0A2U3VHU3 | A0A2U3W8T2 | Growth factor receptor-bound protein 2 isoform X1. | Phosphatidylinositol 3-kinase regulatory subunit beta. | 0.766 |
GRB2 | PIK3R3 | A0A2U3VHU3 | A0A2U3VYN3 | Growth factor receptor-bound protein 2 isoform X1. | Phosphatidylinositol 3-kinase regulatory subunit gamma. | 0.781 |
GRB2 | PTPN11 | A0A2U3VHU3 | A0A2U3WN02 | Growth factor receptor-bound protein 2 isoform X1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.999 |
GRB2 | STAT3 | A0A2U3VHU3 | A0A2U3WNF0 | Growth factor receptor-bound protein 2 isoform X1. | Signal transducer and activator of transcription. | 0.617 |
KIT | CSF1 | A0A2U3ZCP5 | A0A2U3WF20 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.959 |
KIT | GRB2 | A0A2U3ZCP5 | A0A2U3VHU3 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Growth factor receptor-bound protein 2 isoform X1. | 0.984 |
KIT | KITLG | A0A2U3ZCP5 | A0A2U3WZ03 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.999 |
KIT | LOC101374328 | A0A2U3ZCP5 | A0A2U3ZMT2 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Tyrosine-protein phosphatase non-receptor type 11-like. | 0.960 |
KIT | PIK3CA | A0A2U3ZCP5 | A0A2U3VSW6 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.970 |
KIT | PIK3R1 | A0A2U3ZCP5 | A0A2U3X1Z3 | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. | 0.983 |