STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (620 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
   
 
  0.753
LOC101373667
Uncharacterized protein C16orf45 homolog.
      
 0.618
CDC20
Cell division cycle protein 20 homolog.
   
 
 0.617
CDC20B
Cell division cycle protein 20 homolog B.
   
 
 0.617
ECT2
Protein ECT2 isoform X1.
  
    0.617
MAP7D2
MAP7 domain-containing protein 2.
      
 0.522
FZR1
Fizzy-related protein homolog isoform X1.
   
 
  0.472
INTU
Protein inturned.
   
 
  0.456
PLK4
Serine/threonine-protein kinase PLK4 isoform X1.
   
 
 0.453
BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.
   
 
 0.447
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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