ATRIP protein (Odobenus rosmarus) - STRING interaction network

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gene neighborhood

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Score

ATRIP

ATR-interacting protein isoform X1. (792 aa)

Predicted Functional Partners:

ATR

0.998

FANCM

0.983

TOPBP1

0.973

FANCI

0.972

FANCA

0.971

FANCG

0.965

RAD17

0.930

RPA1

0.919

CLSPN

0.917

ATM

0.875

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	A0A2U3VZR5	A0A2U3VQ83	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.998
ATM	ATRIP	A0A2U3VZR5	A0A2U3ZEJ1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR-interacting protein isoform X1.	0.875
ATM	CLSPN	A0A2U3VZR5	A0A2U3W3T0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Claspin isoform X1.	0.618
ATM	FANCA	A0A2U3VZR5	A0A2U3VCS9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group A protein isoform X1.	0.522
ATM	FANCG	A0A2U3VZR5	A0A2U3VCJ8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: Fanconi anemia group G protein.	0.405
ATM	FANCI	A0A2U3VZR5	A0A2U3VST0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group I protein isoform X1.	0.648
ATM	FANCM	A0A2U3VZR5	A0A2U3ZWL6	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group M protein.	0.668
ATM	RAD17	A0A2U3VZR5	A0A2U3W5Q1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint protein RAD17.	0.901
ATM	RPA1	A0A2U3VZR5	A0A2U3ZJH2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.855
ATM	TOPBP1	A0A2U3VZR5	A0A2U3WS35	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA topoisomerase 2-binding protein 1.	0.920
ATR	ATM	A0A2U3VQ83	A0A2U3VZR5	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
ATR	ATRIP	A0A2U3VQ83	A0A2U3ZEJ1	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	ATR-interacting protein isoform X1.	0.998
ATR	CLSPN	A0A2U3VQ83	A0A2U3W3T0	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Claspin isoform X1.	0.747
ATR	FANCA	A0A2U3VQ83	A0A2U3VCS9	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Fanconi anemia group A protein isoform X1.	0.958
ATR	FANCG	A0A2U3VQ83	A0A2U3VCJ8	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	LOW QUALITY PROTEIN: Fanconi anemia group G protein.	0.947
ATR	FANCI	A0A2U3VQ83	A0A2U3VST0	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Fanconi anemia group I protein isoform X1.	0.963
ATR	FANCM	A0A2U3VQ83	A0A2U3ZWL6	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Fanconi anemia group M protein.	0.991
ATR	RAD17	A0A2U3VQ83	A0A2U3W5Q1	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint protein RAD17.	0.913
ATR	RPA1	A0A2U3VQ83	A0A2U3ZJH2	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.958
ATR	TOPBP1	A0A2U3VQ83	A0A2U3WS35	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA topoisomerase 2-binding protein 1.	0.958