STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSPA4Heat shock 70 kDa protein 4 isoform X1. (853 aa)    
Predicted Functional Partners:
STUB1
E3 ubiquitin-protein ligase CHIP.
    
 
 0.940
TJP1
Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family.
    
 0.921
STIP1
Stress-induced-phosphoprotein 1 isoform X1.
  
 0.910
BAG3
BAG family molecular chaperone regulator 3 isoform X1.
   
 0.865
GAK
cyclin-G-associated kinase isoform X1.
    
 0.863
HSP90AB1
Heat shock protein HSP 90-beta isoform X1.
  
 0.844
DNAJB4
dnaJ homolog subfamily B member 4.
 
 0.831
HSPA9
Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family.
  
0.828
BAG1
BAG family molecular chaperone regulator 1.
    
 0.825
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.808
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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