node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | APOA1 | A0A2U3VEQ8 | P0DMS6 | Serum albumin. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.841 |
ALB | EPO | A0A2U3VEQ8 | A0A2U3VUM6 | Serum albumin. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.559 |
ALB | HP | A0A2U3VEQ8 | A0A2U3VF88 | Serum albumin. | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | 0.801 |
ALB | LOC101380043 | A0A2U3VEQ8 | A0A2U3ZSK5 | Serum albumin. | Inhibitor of carbonic anhydrase-like; Belongs to the transferrin family. | 0.600 |
ALB | LOC101380342 | A0A2U3VEQ8 | A0A2U3ZSJ6 | Serum albumin. | Serotransferrin isoform X1; Belongs to the transferrin family. | 0.600 |
ALB | TFRC | A0A2U3VEQ8 | A0A2U3ZBH2 | Serum albumin. | Transferrin receptor protein 1. | 0.649 |
ALB | TTR | A0A2U3VEQ8 | A0A2U3WU96 | Serum albumin. | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. | 0.740 |
APOA1 | ALB | P0DMS6 | A0A2U3VEQ8 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Serum albumin. | 0.841 |
APOA1 | HP | P0DMS6 | A0A2U3VF88 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | 0.798 |
APOA1 | LOC101380043 | P0DMS6 | A0A2U3ZSK5 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Inhibitor of carbonic anhydrase-like; Belongs to the transferrin family. | 0.521 |
APOA1 | LOC101380342 | P0DMS6 | A0A2U3ZSJ6 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Serotransferrin isoform X1; Belongs to the transferrin family. | 0.521 |
APOA1 | TTR | P0DMS6 | A0A2U3WU96 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. | 0.644 |
EPO | ALB | A0A2U3VUM6 | A0A2U3VEQ8 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Serum albumin. | 0.559 |
EPO | LOC101380043 | A0A2U3VUM6 | A0A2U3ZSK5 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Inhibitor of carbonic anhydrase-like; Belongs to the transferrin family. | 0.580 |
EPO | LOC101380342 | A0A2U3VUM6 | A0A2U3ZSJ6 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Serotransferrin isoform X1; Belongs to the transferrin family. | 0.580 |
EPO | TFRC | A0A2U3VUM6 | A0A2U3ZBH2 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Transferrin receptor protein 1. | 0.453 |
HP | ALB | A0A2U3VF88 | A0A2U3VEQ8 | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | Serum albumin. | 0.801 |
HP | APOA1 | A0A2U3VF88 | P0DMS6 | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.798 |
HP | LOC101380043 | A0A2U3VF88 | A0A2U3ZSK5 | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | Inhibitor of carbonic anhydrase-like; Belongs to the transferrin family. | 0.521 |
HP | LOC101380342 | A0A2U3VF88 | A0A2U3ZSJ6 | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. | Serotransferrin isoform X1; Belongs to the transferrin family. | 0.521 |