LOC101365475 protein (Odobenus rosmarus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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LOC101365475

Mitochondrial amidoxime reducing component 2. (235 aa)

Predicted Functional Partners:

LOC101386608

0.791

FAR2

0.527

SUOX

0.524

PLD5

0.524

NPSR1

0.523

LOC101370459

0.522

BFSP2

0.520

LOC101377753

0.518

LOC101378540

0.464

PAPSS2

0.464

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFSP2	FAR2	A0A2U3WS55	A0A2U3WAG3	Phakinin isoform X1; Belongs to the intermediate filament family.	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	0.626
BFSP2	LOC101365475	A0A2U3WS55	A0A2U3ZVT5	Phakinin isoform X1; Belongs to the intermediate filament family.	Mitochondrial amidoxime reducing component 2.	0.520
BFSP2	NPSR1	A0A2U3WS55	A0A2U3X4R4	Phakinin isoform X1; Belongs to the intermediate filament family.	LOW QUALITY PROTEIN: neuropeptide S receptor.	0.533
BFSP2	PLD5	A0A2U3WS55	A0A2U3WZQ6	Phakinin isoform X1; Belongs to the intermediate filament family.	Inactive phospholipase D5 isoform X1.	0.567
FAR2	BFSP2	A0A2U3WAG3	A0A2U3WS55	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Phakinin isoform X1; Belongs to the intermediate filament family.	0.626
FAR2	LOC101365475	A0A2U3WAG3	A0A2U3ZVT5	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Mitochondrial amidoxime reducing component 2.	0.527
FAR2	NPSR1	A0A2U3WAG3	A0A2U3X4R4	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	LOW QUALITY PROTEIN: neuropeptide S receptor.	0.672
FAR2	PAPSS2	A0A2U3WAG3	A0A2U3WLE6	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2.	0.456
FAR2	PLD5	A0A2U3WAG3	A0A2U3WZQ6	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Inactive phospholipase D5 isoform X1.	0.680
LOC101365475	BFSP2	A0A2U3ZVT5	A0A2U3WS55	Mitochondrial amidoxime reducing component 2.	Phakinin isoform X1; Belongs to the intermediate filament family.	0.520
LOC101365475	FAR2	A0A2U3ZVT5	A0A2U3WAG3	Mitochondrial amidoxime reducing component 2.	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	0.527
LOC101365475	LOC101370459	A0A2U3ZVT5	A0A2U3VFA7	Mitochondrial amidoxime reducing component 2.	Cytochrome b5 type B; Belongs to the cytochrome b5 family.	0.522
LOC101365475	LOC101377753	A0A2U3ZVT5	A0A2U3X266	Mitochondrial amidoxime reducing component 2.	Cytochrome b5 isoform X1; Belongs to the cytochrome b5 family.	0.518
LOC101365475	LOC101378540	A0A2U3ZVT5	A0A2U3VQI5	Mitochondrial amidoxime reducing component 2.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.464
LOC101365475	LOC101386608	A0A2U3ZVT5	A0A2U3WH08	Mitochondrial amidoxime reducing component 2.	Cytochrome b5 reductase 4 isoform X1.	0.791
LOC101365475	NPSR1	A0A2U3ZVT5	A0A2U3X4R4	Mitochondrial amidoxime reducing component 2.	LOW QUALITY PROTEIN: neuropeptide S receptor.	0.523
LOC101365475	PAPSS2	A0A2U3ZVT5	A0A2U3WLE6	Mitochondrial amidoxime reducing component 2.	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2.	0.464
LOC101365475	PLD5	A0A2U3ZVT5	A0A2U3WZQ6	Mitochondrial amidoxime reducing component 2.	Inactive phospholipase D5 isoform X1.	0.524
LOC101365475	SUOX	A0A2U3ZVT5	A0A2U3W1C1	Mitochondrial amidoxime reducing component 2.	Sulfite oxidase, mitochondrial.	0.524
LOC101370459	LOC101365475	A0A2U3VFA7	A0A2U3ZVT5	Cytochrome b5 type B; Belongs to the cytochrome b5 family.	Mitochondrial amidoxime reducing component 2.	0.522

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Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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