STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)    
Predicted Functional Partners:
LOC102746004
Bcl-2-like protein 11-like isoform X2.
    
 0.998
BAK1
Bcl-2 homologous antagonist/killer.
    
0.996
LOC102734861
BH3-interacting domain death agonist-like.
    
 0.993
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.984
KRAS
GTPase KRas isoform X2.
     
 0.976
PMAIP1
Phorbol-12-myristate-13-acetate-induced protein 1.
    
 0.959
LOC102726691
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2.
    
 0.948
PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1.
    
 0.946
LOC102750923
Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    
 0.941
LOC102729504
Apoptosis regulator BAX-like.
    
 0.937
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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