STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IDEInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1019 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.993
APP
Amyloid beta A4 protein.
    
 
 0.949
IAPP
Islet amyloid polypeptide.
    
 
 0.923
CTSD
Cathepsin D; Belongs to the peptidase A1 family.
     
 0.884
UBA52
ubiquitin-60S ribosomal protein L40 isoform X3.
    
  0.881
LOC102750322
polyubiquitin-B-like.
    
  0.852
IGF2
Insulin-like growth factor II.
    
 
 0.846
NPPA
Natriuretic peptides A.
    
 
 0.791
MMEL1
Membrane metallo-endopeptidase-like 1.
      
 0.790
NPPB
Natriuretic peptides B.
    
 
 0.785
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.