STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD83CD83 antigen isoform X1. (199 aa)    
Predicted Functional Partners:
CD80
LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.
   
  
 0.808
CD40
Tumor necrosis factor receptor superfamily member 5.
   
  
 0.789
CSF2
Granulocyte-macrophage colony-stimulating factor.
      
 0.769
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.
      
 0.680
CCR7
c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.679
TNF
Tumor necrosis factor; Belongs to the tumor necrosis factor family.
   
  
 0.658
CD19
B-lymphocyte antigen CD19.
   
  
 0.639
CD4
T-cell surface glycoprotein CD4.
      
 0.630
LOC102743181
CD209 antigen-like protein 2-like isoform X1.
   
  
 0.626
IL10
Interleukin-10.
      
 0.624
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.