STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAD18E3 ubiquitin-protein ligase RAD18. (500 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.991
UBE2B
Ubiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.956
UBE2A
Ubiquitin-conjugating enzyme E2 A isoform X1; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.956
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 
 0.936
FANCM
Fanconi anemia group M protein.
   
 
 0.935
ANKRD32
Ankyrin repeat domain-containing protein 32 isoform X1.
    
 
 0.927
LOC102750322
polyubiquitin-B-like.
    
 0.921
LOC102726122
Ubiquitin-conjugating enzyme E2 U-like.
    
 0.880
LOC102738042
Ubiquitin-conjugating enzyme E2 U-like.
    
 0.880
POLH
DNA polymerase eta isoform X1.
    
 
 0.879
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.