STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)    
Predicted Functional Partners:
LOC102736516
Phosphatidylinositol 3-kinase regulatory subunit alpha-like.
   
 0.999
PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma.
   
 0.996
RRAS
Ras-related protein R-Ras.
   
 0.995
MRAS
Ras-related protein M-Ras.
   
 0.994
KRAS
GTPase KRas isoform X2.
   
 0.987
NRAS
GTPase NRas.
   
 0.978
LOC102740654
Phosphoinositide 3-kinase regulatory subunit 5-like.
   
 0.973
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.972
LOC102751021
Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1.
   
 0.971
LOC102737030
Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.969
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.