DCUN1D3 protein (Leptonychotes weddellii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DCUN1D3

DCN1-like protein. (304 aa)

Predicted Functional Partners:

CUL1

0.947

UBE2F

0.945

RBX1

0.904

UBE2M

0.860

CACUL1

0.773

LOC102742823

0.768

LOC102734241

0.745

UBA3

0.721

CUL4A

0.718

RNF7

0.711

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACUL1	CUL4A	A0A2U3XY19	A0A2U3Z9K6	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	LOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family.	0.662
CACUL1	DCUN1D3	A0A2U3XY19	A0A2U3YQZ0	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	DCN1-like protein.	0.773
CACUL1	LOC102734241	A0A2U3XY19	A0A2U3XIE0	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	Cullin-associated NEDD8-dissociated protein 1-like isoform X1.	0.872
CACUL1	LOC102742823	A0A2U3XY19	A0A2U3YMC0	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	Cullin-5-like; Belongs to the cullin family.	0.543
CACUL1	RBX1	A0A2U3XY19	A0A2U3XEU7	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	E3 ubiquitin-protein ligase RBX1 isoform X3.	0.882
CACUL1	RNF7	A0A2U3XY19	A0A2U3Y1L2	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	RING-box protein 2 isoform X1.	0.882
CACUL1	UBA3	A0A2U3XY19	A0A2U3XY38	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	0.733
CACUL1	UBE2F	A0A2U3XY19	A0A2U3YTD5	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	NEDD8-conjugating enzyme UBE2F isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.815
CACUL1	UBE2M	A0A2U3XY19	A0A2U3YVU4	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.	0.815
CUL1	CUL4A	A0A2U3XHJ1	A0A2U3Z9K6	Cullin-1; Belongs to the cullin family.	LOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family.	0.682
CUL1	DCUN1D3	A0A2U3XHJ1	A0A2U3YQZ0	Cullin-1; Belongs to the cullin family.	DCN1-like protein.	0.947
CUL1	LOC102734241	A0A2U3XHJ1	A0A2U3XIE0	Cullin-1; Belongs to the cullin family.	Cullin-associated NEDD8-dissociated protein 1-like isoform X1.	0.941
CUL1	LOC102742823	A0A2U3XHJ1	A0A2U3YMC0	Cullin-1; Belongs to the cullin family.	Cullin-5-like; Belongs to the cullin family.	0.963
CUL1	RBX1	A0A2U3XHJ1	A0A2U3XEU7	Cullin-1; Belongs to the cullin family.	E3 ubiquitin-protein ligase RBX1 isoform X3.	0.997
CUL1	RNF7	A0A2U3XHJ1	A0A2U3Y1L2	Cullin-1; Belongs to the cullin family.	RING-box protein 2 isoform X1.	0.914
CUL1	UBA3	A0A2U3XHJ1	A0A2U3XY38	Cullin-1; Belongs to the cullin family.	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	0.806
CUL1	UBE2F	A0A2U3XHJ1	A0A2U3YTD5	Cullin-1; Belongs to the cullin family.	NEDD8-conjugating enzyme UBE2F isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.904
CUL1	UBE2M	A0A2U3XHJ1	A0A2U3YVU4	Cullin-1; Belongs to the cullin family.	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.	0.904
CUL4A	CACUL1	A0A2U3Z9K6	A0A2U3XY19	LOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family.	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family.	0.662
CUL4A	CUL1	A0A2U3Z9K6	A0A2U3XHJ1	LOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family.	Cullin-1; Belongs to the cullin family.	0.682

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044271

Cellular nitrogen compound biosynthetic process

10 of 452

1.03

1.3

8.65e-09

GO:0006796

Phosphate-containing compound metabolic process

9 of 413

1.03

1.22

1.79e-07

GO:1901566

Organonitrogen compound biosynthetic process

10 of 527

0.97

1.14

3.48e-08

GO:0044237

Cellular metabolic process

11 of 2057

0.42

0.35

0.00066

GO:0044238

Primary metabolic process

10 of 1775

0.44

0.35

0.0029

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

8 of 8

2.69

8.06

1.00e-16

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 2

2.69

1.6

0.0012

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

8 of 8

2.69

8.41

1.67e-17

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.69

5.22

1.05e-10

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 3

2.69

3.02

2.44e-06

GO:0032991

Protein-containing complex

9 of 240

1.26

1.92

9.78e-10

GO:0005622

Intracellular anatomical structure

11 of 1659

0.51

0.45

3.85e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:353

ATP synthesis

8 of 8

2.69

7.98

1.54e-16

CL:96

Translation, and Protein transport

10 of 141

1.54

3.13

1.02e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 49

1.95

5.19

8.19e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

8 of 8

2.69

8.25

3.84e-17

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.69

4.98

3.22e-10

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 3

2.69

2.8

6.57e-06

GOCC:0005622

Intracellular

10 of 2071

0.37

0.29

0.0167

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 8

2.69

8.32

2.67e-17

KW-0066

ATP synthesis

8 of 8

2.69

8.32

2.67e-17

KW-0139

CF(1)

5 of 5

2.69

5.12

1.68e-10

KW-0138

CF(0)

3 of 3

2.69

2.91

3.92e-06

KW-1003

Cell membrane

8 of 231

1.23

1.67

7.25e-08

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 2

2.69

0.98

0.0167

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036121

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

2 of 2

2.69

0.77

0.0413

IPR020003

ATPase, alpha/beta subunit, nucleotide-binding domain, active site

2 of 2

2.69

0.77

0.0413

IPR004100

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain

2 of 2

2.69

0.77

0.0413

IPR000194

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

2 of 3

2.51

0.76

0.0413

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