STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
S100A13Protein S100-A13; Belongs to the S-100 family. (98 aa)    
Predicted Functional Partners:
LOC102744822
Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]
    
 
 0.936
IL1A
Interleukin-1; Belongs to the IL-1 family.
    
 
 0.913
SYT2
Synaptotagmin-2.
    
 
 0.801
LOC102749626
Synaptotagmin-1-like.
    
 
 0.801
AGER
Advanced glycosylation end product-specific receptor.
    
 
 0.795
LOC102734264
Protein S100; Belongs to the S-100 family.
   
  
 0.762
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
    
 
 0.612
S100A2
Protein S100; Belongs to the S-100 family.
      
 0.576
LOC102726679
Protein S100-A10-like; Belongs to the S-100 family.
      
 0.569
C1QL4
Complement C1q-like protein 4.
      
 0.554
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.