STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC1027427483 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like. (288 aa)    
Predicted Functional Partners:
LOC102743616
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 0.983
LOC102745940
Steroid 17-alpha-hydroxylase/17,20 lyase-like; Belongs to the cytochrome P450 family.
   
 0.975
FAU
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.971
LOC102731614
Aromatase-like isoform X1; Belongs to the cytochrome P450 family.
   
 0.970
LOC102737081
Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family.
   
 0.958
HSD17B3
Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.955
LOC102744148
25-hydroxycholesterol 7-alpha-hydroxylase-like; Belongs to the cytochrome P450 family.
   
 0.954
SRD5A1
3-oxo-5-alpha-steroid 4-dehydrogenase 1.
     
 0.943
SRD5A2
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
     
 0.940
LOC102731486
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.939
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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