LOC102741650 protein (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

LOC102741650

NHS-like protein 2-like. (1141 aa)

Predicted Functional Partners:

COMMD6

0.606

RTP1

0.583

MMRN2

0.581

SLC39A12

0.552

ABHD12B

0.549

ABHD12

0.549

FKBP11

0.539

AP1AR

0.489

LOC102748076

0.478

PMAIP1

0.476

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD12	LOC102741650	A0A2U3YPK6	A0A2U3Z4B4	Monoacylglycerol lipase ABHD12.	NHS-like protein 2-like.	0.549
ABHD12	PMAIP1	A0A2U3YPK6	A0A2U3XJD5	Monoacylglycerol lipase ABHD12.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.475
ABHD12B	LOC102741650	A0A2U3XIC3	A0A2U3Z4B4	Abhydrolase domain-containing protein 12B.	NHS-like protein 2-like.	0.549
ABHD12B	PMAIP1	A0A2U3XIC3	A0A2U3XJD5	Abhydrolase domain-containing protein 12B.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.475
AP1AR	LOC102741650	A0A2U3XKC5	A0A2U3Z4B4	AP-1 complex-associated regulatory protein isoform X1.	NHS-like protein 2-like.	0.489
COMMD6	FKBP11	A0A2U3XQE5	A0A2U3XCW1	COMM domain-containing protein 6 isoform X1.	Peptidylprolyl isomerase.	0.497
COMMD6	LOC102741650	A0A2U3XQE5	A0A2U3Z4B4	COMM domain-containing protein 6 isoform X1.	NHS-like protein 2-like.	0.606
COMMD6	MMRN2	A0A2U3XQE5	A0A2U3YXG5	COMM domain-containing protein 6 isoform X1.	Multimerin-2-like.	0.574
COMMD6	RTP1	A0A2U3XQE5	A0A2U3YDB7	COMM domain-containing protein 6 isoform X1.	Receptor-transporting protein 1.	0.545
COMMD6	SLC39A12	A0A2U3XQE5	A0A2U3Z4F3	COMM domain-containing protein 6 isoform X1.	Zinc transporter ZIP12.	0.523
FKBP11	COMMD6	A0A2U3XCW1	A0A2U3XQE5	Peptidylprolyl isomerase.	COMM domain-containing protein 6 isoform X1.	0.497
FKBP11	LOC102741650	A0A2U3XCW1	A0A2U3Z4B4	Peptidylprolyl isomerase.	NHS-like protein 2-like.	0.539
FKBP11	MMRN2	A0A2U3XCW1	A0A2U3YXG5	Peptidylprolyl isomerase.	Multimerin-2-like.	0.509
FKBP11	RTP1	A0A2U3XCW1	A0A2U3YDB7	Peptidylprolyl isomerase.	Receptor-transporting protein 1.	0.487
FKBP11	SLC39A12	A0A2U3XCW1	A0A2U3Z4F3	Peptidylprolyl isomerase.	Zinc transporter ZIP12.	0.473
LOC102741650	ABHD12	A0A2U3Z4B4	A0A2U3YPK6	NHS-like protein 2-like.	Monoacylglycerol lipase ABHD12.	0.549
LOC102741650	ABHD12B	A0A2U3Z4B4	A0A2U3XIC3	NHS-like protein 2-like.	Abhydrolase domain-containing protein 12B.	0.549
LOC102741650	AP1AR	A0A2U3Z4B4	A0A2U3XKC5	NHS-like protein 2-like.	AP-1 complex-associated regulatory protein isoform X1.	0.489
LOC102741650	COMMD6	A0A2U3Z4B4	A0A2U3XQE5	NHS-like protein 2-like.	COMM domain-containing protein 6 isoform X1.	0.606
LOC102741650	FKBP11	A0A2U3Z4B4	A0A2U3XCW1	NHS-like protein 2-like.	Peptidylprolyl isomerase.	0.539

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043928

Exonucleolytic catabolism of deadenylated mRNA

3 of 29

2.72

2.1

0.00014

GO:0010497

Plasmodesmata-mediated intercellular transport

2 of 30

2.53

1.33

0.0037

GO:2000280

Regulation of root development

2 of 92

2.04

0.9

0.0200

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004535

poly(A)-specific ribonuclease activity

3 of 26

2.77

2.33

5.39e-05

GO:0005351

Carbohydrate:proton symporter activity

3 of 40

2.58

2.18

9.09e-05

GO:0030145

Manganese ion binding

2 of 136

1.87

0.7

0.0475

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030015

CCR4-NOT core complex

3 of 34

2.65

2.38

3.98e-05

GO:0000932

P-body

3 of 145

2.02

1.55

0.00089

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26059100

(2015) Comparative transcriptomics analysis reveals difference of key gene expression between banana and plantain in response to cold stress.

7 of 115

2.49

5.8

2.07e-12

PMID:36457753

(2022) Chromosome-level genome assembly of Dongxiang wild rice (Oryza rufipogon) provides insights into resistance to disease and freezing.

3 of 11

3.14

2.48

3.28e-05

PMID:27379110

(2016) Transcriptome- Assisted Label-Free Quantitative Proteomics Analysis Reveals Novel Insights into Piper nigrum-Phytophthora capsici Phytopathosystem.

3 of 15

3.01

2.37

4.90e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:55842

Mixed, incl. Serine carboxypeptidases, histidine active site, and Gibberellin 20-oxidase activity

5 of 32

2.9

5.04

4.21e-10

CL:55889

Plasmodesmata-mediated intercellular transport, and Cyclophilin-type peptidyl-prolyl cis-trans isomerase

3 of 5

3.48

3.45

6.04e-07

CL:49891

Mixed, incl. Polyol transporter 1-6, and Alternative mRNA splicing, via spliceosome

3 of 10

3.18

3.08

2.57e-06

CL:6282

CCR4-NOT complex

3 of 47

2.51

2.09

0.00013

CL:6285

CCR4-NOT complex

2 of 40

2.4

0.98

0.0160

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gmx03018

RNA degradation

3 of 179

1.93

1.56

0.00073

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6804115

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

3 of 47

2.51

2.15

9.72e-05

MAP-6791312

TP53 Regulates Transcription of Cell Cycle Genes

3 of 53

2.46

2.14

9.72e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 185

1.92

1.38

0.0018

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030015

CCR4-NOT core complex

3 of 33

2.66

2.27

6.52e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04857

CAF1 family ribonuclease

3 of 14

3.04

2.71

1.17e-05

PF00083

Sugar (and other) transporter

3 of 111

2.14

1.4

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039637

CCR4-NOT transcription complex subunit 7/8/Pop2

3 of 12

3.1

2.56

2.29e-05

IPR006941

Ribonuclease CAF1

3 of 15

3.01

2.55

2.29e-05

IPR045262

Sugar transport protein STP/Polyol transporter PLT, plant

3 of 47

2.51

1.88

0.00033

IPR044776

Polyol transporter 1-6

2 of 3

3.53

1.73

0.00078

IPR003663

Sugar/inositol transporter

3 of 111

2.14

1.38

0.0024

(more ...)

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