LOC102733263 protein (Leptonychotes weddellii)

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LOC102733263

Double-strand break repair protein MRE11A-like. (83 aa)

Predicted Functional Partners:

RAD50

0.999

ATM

0.996

LOC102739775

0.989

RBBP8

0.983

EXO1

0.977

RECQL5

0.968

RAD51

0.949

MEIOB

0.936

PWWP2A

0.934

GEN1

0.915

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	EXO1	A0A2U3YJR1	A0A2U3YW79	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: exonuclease 1.	0.901
ATM	GEN1	A0A2U3YJR1	A0A2U3XNJ1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Flap endonuclease GEN homolog 1.	0.595
ATM	LOC102733263	A0A2U3YJR1	A0A2U3Z4T6	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein MRE11A-like.	0.996
ATM	LOC102739775	A0A2U3YJR1	A0A2U3Z3N7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 1 susceptibility protein homolog.	0.990
ATM	MEIOB	A0A2U3YJR1	A0A2U3YE20	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiosis-specific with OB domain-containing protein.	0.748
ATM	RAD50	A0A2U3YJR1	A0A2U3XTH3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein RAD50.	0.989
ATM	RAD51	A0A2U3YJR1	A0A2U3YFP3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.910
ATM	RBBP8	A0A2U3YJR1	A0A2U3XTB6	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA endonuclease RBBP8.	0.876
ATM	RECQL5	A0A2U3YJR1	A0A2U3X9V4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATP-dependent DNA helicase Q5.	0.852
EXO1	ATM	A0A2U3YW79	A0A2U3YJR1	LOW QUALITY PROTEIN: exonuclease 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.901
EXO1	GEN1	A0A2U3YW79	A0A2U3XNJ1	LOW QUALITY PROTEIN: exonuclease 1.	Flap endonuclease GEN homolog 1.	0.720
EXO1	LOC102733263	A0A2U3YW79	A0A2U3Z4T6	LOW QUALITY PROTEIN: exonuclease 1.	Double-strand break repair protein MRE11A-like.	0.977
EXO1	LOC102739775	A0A2U3YW79	A0A2U3Z3N7	LOW QUALITY PROTEIN: exonuclease 1.	Breast cancer type 1 susceptibility protein homolog.	0.890
EXO1	MEIOB	A0A2U3YW79	A0A2U3YE20	LOW QUALITY PROTEIN: exonuclease 1.	Meiosis-specific with OB domain-containing protein.	0.813
EXO1	PWWP2A	A0A2U3YW79	A0A2U3YQD8	LOW QUALITY PROTEIN: exonuclease 1.	PWWP domain-containing protein 2A.	0.783
EXO1	RAD50	A0A2U3YW79	A0A2U3XTH3	LOW QUALITY PROTEIN: exonuclease 1.	DNA repair protein RAD50.	0.875
EXO1	RAD51	A0A2U3YW79	A0A2U3YFP3	LOW QUALITY PROTEIN: exonuclease 1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.987
EXO1	RBBP8	A0A2U3YW79	A0A2U3XTB6	LOW QUALITY PROTEIN: exonuclease 1.	DNA endonuclease RBBP8.	0.939
EXO1	RECQL5	A0A2U3YW79	A0A2U3X9V4	LOW QUALITY PROTEIN: exonuclease 1.	ATP-dependent DNA helicase Q5.	0.922
GEN1	ATM	A0A2U3XNJ1	A0A2U3YJR1	Flap endonuclease GEN homolog 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.595