STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)    
Predicted Functional Partners:
STARD3NL
MLN64 N-terminal domain homolog.
 
   
 0.979
VDAC3
Voltage-dependent anion-selective channel protein 3 isoform X1.
     
 0.912
VDAC2
Voltage-dependent anion-selective channel protein 2 isoform X1.
     
 0.912
LOC102743616
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 
 0.877
LOC102737081
Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family.
   
 
 0.770
LOC102745940
Steroid 17-alpha-hydroxylase/17,20 lyase-like; Belongs to the cytochrome P450 family.
   
 
 0.769
SRD5A1
3-oxo-5-alpha-steroid 4-dehydrogenase 1.
      
 0.769
MC2R
Adrenocorticotropic hormone receptor.
      
 0.769
LOC102742748
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like.
   
  
 0.769
HSD17B3
Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.769
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.