STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)    
Predicted Functional Partners:
CDK4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.999
CDK2
Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.
   
 0.998
CCNE1
G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.997
CCND1
G1/S-specific cyclin-D1; Belongs to the cyclin family.
   
 0.997
LOC102737670
Cyclin-dependent kinase 6-like.
   
 0.996
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.993
CCND3
G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.
   
 0.990
CCNE2
G1/S-specific cyclin-E2; Belongs to the cyclin family.
   
 0.990
LOC102746125
LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family.
    
 0.983
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.975
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.