C821_00327 protein (Lactobacillus sp. ASF360)

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Score

C821_00327

Hypothetical protein; Belongs to the ClpA/ClpB family. (707 aa)

Predicted Functional Partners:

dnaK

0.970

clpP

0.954

C821_01250

0.881

dnaJ

0.875

C821_01567

0.819

grpE

0.803

groS

0.730

groL

0.715

hrcA

0.651

C821_01810

0.577

Your Current Organism:

Lactobacillus sp. ASF360

NCBI taxonomy Id: 97137
Other names: L. sp. ASF360

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C821_00327	C821_01250	C821_00327	C821_01250	Hypothetical protein; Belongs to the ClpA/ClpB family.	Hypothetical protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.	0.881
C821_00327	C821_01567	C821_00327	C821_01567	Hypothetical protein; Belongs to the ClpA/ClpB family.	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	0.819
C821_00327	C821_01810	C821_00327	C821_01810	Hypothetical protein; Belongs to the ClpA/ClpB family.	Protein phosphatase.	0.577
C821_00327	clpP	C821_00327	C821_01181	Hypothetical protein; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.954
C821_00327	dnaJ	C821_00327	C821_00939	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.875
C821_00327	dnaK	C821_00327	C821_00940	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.970
C821_00327	groL	C821_00327	C821_01325	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.715
C821_00327	groS	C821_00327	C821_01326	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.730
C821_00327	grpE	C821_00327	C821_00941	Hypothetical protein; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.803
C821_00327	hrcA	C821_00327	C821_00942	Hypothetical protein; Belongs to the ClpA/ClpB family.	Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.651
C821_01250	C821_00327	C821_01250	C821_00327	Hypothetical protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.	Hypothetical protein; Belongs to the ClpA/ClpB family.	0.881
C821_01567	C821_00327	C821_01567	C821_00327	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Hypothetical protein; Belongs to the ClpA/ClpB family.	0.819
C821_01567	clpP	C821_01567	C821_01181	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.446
C821_01567	dnaJ	C821_01567	C821_00939	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.801
C821_01567	dnaK	C821_01567	C821_00940	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.764
C821_01567	groL	C821_01567	C821_01325	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.432
C821_01567	groS	C821_01567	C821_01326	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.424
C821_01567	grpE	C821_01567	C821_00941	Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.654
C821_01810	C821_00327	C821_01810	C821_00327	Protein phosphatase.	Hypothetical protein; Belongs to the ClpA/ClpB family.	0.577
C821_01810	dnaJ	C821_01810	C821_00939	Protein phosphatase.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.854