| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C821_00249 | C821_00821 | C821_00249 | C821_00821 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, alpha subunit. | 0.819 |
| C821_00249 | dnaG | C821_00249 | C821_00726 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.999 |
| C821_00249 | dnaX | C821_00249 | C821_01369 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.896 |
| C821_00249 | gyrA | C821_00249 | C821_00255 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.530 |
| C821_00249 | polA | C821_00249 | C821_01699 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.752 |
| C821_00727 | C821_00728 | C821_00727 | C821_00728 | RNA polymerase primary sigma factor. | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.900 |
| C821_00727 | C821_00821 | C821_00727 | C821_00821 | RNA polymerase primary sigma factor. | DNA polymerase III, alpha subunit. | 0.464 |
| C821_00727 | dnaG | C821_00727 | C821_00726 | RNA polymerase primary sigma factor. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.903 |
| C821_00727 | dnaX | C821_00727 | C821_01369 | RNA polymerase primary sigma factor. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.408 |
| C821_00727 | glyQ | C821_00727 | C821_00724 | RNA polymerase primary sigma factor. | glycyl-tRNA synthetase alpha subunit. | 0.714 |
| C821_00727 | glyS | C821_00727 | C821_00725 | RNA polymerase primary sigma factor. | glycyl-tRNA synthetase beta subunit. | 0.723 |
| C821_00727 | polA | C821_00727 | C821_01699 | RNA polymerase primary sigma factor. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.525 |
| C821_00728 | C821_00727 | C821_00728 | C821_00727 | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | RNA polymerase primary sigma factor. | 0.900 |
| C821_00728 | C821_00821 | C821_00728 | C821_00821 | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | DNA polymerase III, alpha subunit. | 0.464 |
| C821_00728 | dnaG | C821_00728 | C821_00726 | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.855 |
| C821_00728 | dnaX | C821_00728 | C821_01369 | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.531 |
| C821_00728 | polA | C821_00728 | C821_01699 | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.581 |
| C821_00821 | C821_00249 | C821_00821 | C821_00249 | DNA polymerase III, alpha subunit. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.819 |
| C821_00821 | C821_00727 | C821_00821 | C821_00727 | DNA polymerase III, alpha subunit. | RNA polymerase primary sigma factor. | 0.464 |
| C821_00821 | C821_00728 | C821_00821 | C821_00728 | DNA polymerase III, alpha subunit. | RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.464 |