dnaK protein (Lactobacillus sp. ASF360) - STRING interaction network

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Score

dnaK

Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (616 aa)

Predicted Functional Partners:

dnaJ

0.999

grpE

0.999

groL

0.996

hrcA

0.994

rplP

0.994

groS

0.990

C821_01466

0.975

C821_00327

0.970

C821_01255

0.970

clpP

0.916

Your Current Organism:

Lactobacillus sp. ASF360

NCBI taxonomy Id: 97137
Other names: L. sp. ASF360

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C821_00327	clpP	C821_00327	C821_01181	Hypothetical protein; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.954
C821_00327	dnaJ	C821_00327	C821_00939	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.875
C821_00327	dnaK	C821_00327	C821_00940	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.970
C821_00327	groL	C821_00327	C821_01325	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.715
C821_00327	groS	C821_00327	C821_01326	Hypothetical protein; Belongs to the ClpA/ClpB family.	Chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.730
C821_00327	grpE	C821_00327	C821_00941	Hypothetical protein; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.803
C821_00327	hrcA	C821_00327	C821_00942	Hypothetical protein; Belongs to the ClpA/ClpB family.	Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.651
C821_01255	clpP	C821_01255	C821_01181	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.954
C821_01255	dnaJ	C821_01255	C821_00939	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.875
C821_01255	dnaK	C821_01255	C821_00940	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.970
C821_01255	groL	C821_01255	C821_01325	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.715
C821_01255	groS	C821_01255	C821_01326	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.730
C821_01255	grpE	C821_01255	C821_00941	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.803
C821_01255	hrcA	C821_01255	C821_00942	ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family.	Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.651
C821_01466	clpP	C821_01466	C821_01181	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.962
C821_01466	dnaJ	C821_01466	C821_00939	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperone dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]	0.875
C821_01466	dnaK	C821_01466	C821_00940	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.975
C821_01466	groL	C821_01466	C821_01325	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.733
C821_01466	groS	C821_01466	C821_01326	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.757
C821_01466	grpE	C821_01466	C821_00941	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.803