DFL_009647 protein (Arthrobotrys flagrans) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

DFL_009647

ULP_PROTEASE domain-containing protein. (1111 aa)

Predicted Functional Partners:

DFL_007482

0.986

DFL_003289

0.944

DFL_008221

0.915

DFL_004189

0.744

DFL_004775

0.740

DFL_005034

0.723

DFL_008183

0.698

DFL_007032

0.694

DFL_006195

0.678

DFL_008670

0.675

Your Current Organism:

Arthrobotrys flagrans

NCBI taxonomy Id: 97331
Other names: A. flagrans, Duddingtonia flagrans, Trichothecium flagrans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFL_003289	DFL_004189	A0A437A1F0	A0A437A436	ULP_PROTEASE domain-containing protein.	Ipi1_N domain-containing protein.	0.895
DFL_003289	DFL_004775	A0A437A1F0	A0A437A5X9	ULP_PROTEASE domain-containing protein.	Uncharacterized protein.	0.910
DFL_003289	DFL_005034	A0A437A1F0	A0A437A6K8	ULP_PROTEASE domain-containing protein.	Nsp1_C domain-containing protein.	0.910
DFL_003289	DFL_006195	A0A437A1F0	A0A437A0I9	ULP_PROTEASE domain-containing protein.	Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family.	0.596
DFL_003289	DFL_007032	A0A437A1F0	A0A436ZUH9	ULP_PROTEASE domain-containing protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.923
DFL_003289	DFL_007482	A0A437A1F0	A0A436ZVX6	ULP_PROTEASE domain-containing protein.	Ubiquitin-like domain-containing protein.	0.997
DFL_003289	DFL_008183	A0A437A1F0	A0A436ZNA8	ULP_PROTEASE domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.594
DFL_003289	DFL_008670	A0A437A1F0	A0A436ZPF5	ULP_PROTEASE domain-containing protein.	CLP1_P domain-containing protein.	0.892
DFL_003289	DFL_009647	A0A437A1F0	A0A436ZS95	ULP_PROTEASE domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.944
DFL_004189	DFL_003289	A0A437A436	A0A437A1F0	Ipi1_N domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.895
DFL_004189	DFL_004775	A0A437A436	A0A437A5X9	Ipi1_N domain-containing protein.	Uncharacterized protein.	0.918
DFL_004189	DFL_008670	A0A437A436	A0A436ZPF5	Ipi1_N domain-containing protein.	CLP1_P domain-containing protein.	0.956
DFL_004189	DFL_009647	A0A437A436	A0A436ZS95	Ipi1_N domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.744
DFL_004775	DFL_003289	A0A437A5X9	A0A437A1F0	Uncharacterized protein.	ULP_PROTEASE domain-containing protein.	0.910
DFL_004775	DFL_004189	A0A437A5X9	A0A437A436	Uncharacterized protein.	Ipi1_N domain-containing protein.	0.918
DFL_004775	DFL_008670	A0A437A5X9	A0A436ZPF5	Uncharacterized protein.	CLP1_P domain-containing protein.	0.997
DFL_004775	DFL_009647	A0A437A5X9	A0A436ZS95	Uncharacterized protein.	ULP_PROTEASE domain-containing protein.	0.740
DFL_005034	DFL_003289	A0A437A6K8	A0A437A1F0	Nsp1_C domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.910
DFL_005034	DFL_007032	A0A437A6K8	A0A436ZUH9	Nsp1_C domain-containing protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.994
DFL_005034	DFL_007482	A0A437A6K8	A0A436ZVX6	Nsp1_C domain-containing protein.	Ubiquitin-like domain-containing protein.	0.991

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.749

expected number of edges:

15

PPI enrichment p-value:

6.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034728

Nucleosome organization

4 of 69

2.32

2.9

7.50e-06

GO:0006334

Nucleosome assembly

3 of 33

2.51

2.42

8.06e-05

GO:0031497

Chromatin assembly

4 of 130

2.04

2.38

3.52e-05

GO:0006325

Chromatin organization

5 of 306

1.77

2.26

1.48e-05

GO:0051276

Chromosome organization

6 of 534

1.6

2.14

6.62e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003682

Chromatin binding

6 of 252

1.93

3.48

2.66e-08

GO:0031492

Nucleosomal DNA binding

3 of 12

2.95

3.16

6.17e-06

GO:0030527

Structural constituent of chromatin

3 of 12

2.95

3.16

6.17e-06

GO:0046982

Protein heterodimerization activity

3 of 115

1.97

1.65

0.0010

GO:0005515

Protein binding

8 of 2974

0.98

1.04

6.58e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000785

Chromatin

6 of 204

2.02

3.97

4.07e-09

GO:0000786

Nucleosome

3 of 20

2.73

3.16

5.15e-06

GO:0005694

Chromosome

7 of 542

1.66

3.04

4.07e-09

GO:0005700

Polytene chromosome

3 of 165

1.81

1.56

0.0011

GO:0140513

Nuclear protein-containing complex

5 of 743

1.38

1.53

7.98e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36760483

(2022) Sympatry of genetic lineages of Parisotomanotabilis s. l. (Collembola, Isotomidae) in the East European Plain.

2 of 2

3.55

2.59

6.42e-05

PMID:31919378

(2020) Rapid and cost-effective generation of single specimen multilocus barcoding data from whole arthropod communities by multiple levels of multiplexing.

2 of 2

3.55

2.59

6.42e-05

PMID:28397786

(2017) Cretaceous origin of the unique prey-capture apparatus in mega-diverse genus: stem lineage of Steninae rove beetles discovered in Burmese amber.

2 of 2

3.55

2.59

6.42e-05

PMID:28170395

(2017) Genetic structure and distribution of Parisotoma notabilis (Collembola) in Europe: Cryptic diversity, split of lineages and colonization patterns.

2 of 2

3.55

2.59

6.42e-05

PMID:34542224

(2022) Delete and survive: strategies of programmed genetic material elimination in eukaryotes.

2 of 6

3.08

2.56

6.42e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2638

Mixed, incl. Histone deacetylase complex, and Structural constituent of chromatin

4 of 79

2.26

2.71

1.46e-05

CL:2650

Structural constituent of chromatin, and Set1C/COMPASS complex

3 of 21

2.71

2.7

3.08e-05

CL:2652

Structural constituent of chromatin, and Set1C/COMPASS complex

2 of 16

2.65

1.5

0.0033

CL:3032

Mixed, incl. Chromo/chromo shadow domain, and Transcriptional Regulation by E2F6

2 of 56

2.11

0.88

0.0325

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8878171

Transcriptional regulation by RUNX1

4 of 207

1.84

2.02

0.00010

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 99

2.03

1.76

0.00067

MAP-8936459

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

3 of 133

1.91

1.57

0.0013

MAP-212436

Generic Transcription Pathway

6 of 1073

1.3

1.39

0.00010

MAP-73857

RNA Polymerase II Transcription

6 of 1198

1.25

1.32

0.00010

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.95

3.25

4.25e-06

GOCC:0000785

Chromatin

5 of 186

1.98

3.01

9.07e-07

GOCC:0032991

Protein-containing complex

6 of 3032

0.85

0.62

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 31

2.54

2.99

7.81e-06

KW-0539

Nucleus

6 of 495

1.64

2.59

2.09e-07

KW-0238

DNA-binding

5 of 371

1.68

2.37

2.84e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000164

Histone H3/CENP-A

3 of 5

3.33

3.38

3.11e-06

IPR007125

Histone H2A/H2B/H3

3 of 8

3.13

3.26

4.58e-06

IPR009072

Histone-fold

3 of 25

2.63

2.52

6.05e-05

IPR023780

Chromo domain

2 of 23

2.49

1.03

0.0198

IPR016197

Chromo-like domain superfamily

2 of 30

2.38

0.99

0.0229

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

3 of 5

3.33

3.9

4.21e-07

SM00298

Chromatin organization modifier domain

2 of 30

2.38

1.23

0.0088

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