DFL_006345 protein (Arthrobotrys flagrans) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

DFL_006345

Uncharacterized protein. (109 aa)

Predicted Functional Partners:

DFL_007087

0.674

DFL_009514

0.608

DFL_005029

0.567

DFL_000690

0.544

DFL_000361

0.515

DFL_006397

0.514

DFL_005137

0.507

DFL_005102

0.485

DFL_001033

0.482

DFL_006718

0.480

Your Current Organism:

Arthrobotrys flagrans

NCBI taxonomy Id: 97331
Other names: A. flagrans, Duddingtonia flagrans, Trichothecium flagrans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFL_000361	DFL_000690	A0A437AE35	A0A437AEG6	Sulfhydryl oxidase.	Uncharacterized protein.	0.986
DFL_000361	DFL_006345	A0A437AE35	A0A437A041	Sulfhydryl oxidase.	Uncharacterized protein.	0.515
DFL_000361	DFL_007087	A0A437AE35	A0A436ZUP8	Sulfhydryl oxidase.	Uncharacterized protein.	0.738
DFL_000361	DFL_009514	A0A437AE35	A0A436ZS63	Sulfhydryl oxidase.	zf-Tim10_DDP domain-containing protein.	0.566
DFL_000690	DFL_000361	A0A437AEG6	A0A437AE35	Uncharacterized protein.	Sulfhydryl oxidase.	0.986
DFL_000690	DFL_005137	A0A437AEG6	A0A437A6R6	Uncharacterized protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.456
DFL_000690	DFL_006345	A0A437AEG6	A0A437A041	Uncharacterized protein.	Uncharacterized protein.	0.544
DFL_000690	DFL_006718	A0A437AEG6	A0A436ZTP9	Uncharacterized protein.	Cytochrome c oxidase assembly protein CtaG/Cox11.	0.546
DFL_000690	DFL_007087	A0A437AEG6	A0A436ZUP8	Uncharacterized protein.	Uncharacterized protein.	0.968
DFL_000690	DFL_009514	A0A437AEG6	A0A436ZS63	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.896
DFL_001033	DFL_005029	A0A437AG07	A0A437A6W6	Thioredoxin domain-containing protein.	Uncharacterized protein.	0.451
DFL_001033	DFL_006345	A0A437AG07	A0A437A041	Thioredoxin domain-containing protein.	Uncharacterized protein.	0.482
DFL_001033	DFL_006718	A0A437AG07	A0A436ZTP9	Thioredoxin domain-containing protein.	Cytochrome c oxidase assembly protein CtaG/Cox11.	0.853
DFL_001033	DFL_007087	A0A437AG07	A0A436ZUP8	Thioredoxin domain-containing protein.	Uncharacterized protein.	0.715
DFL_005029	DFL_001033	A0A437A6W6	A0A437AG07	Uncharacterized protein.	Thioredoxin domain-containing protein.	0.451
DFL_005029	DFL_006345	A0A437A6W6	A0A437A041	Uncharacterized protein.	Uncharacterized protein.	0.567
DFL_005029	DFL_006718	A0A437A6W6	A0A436ZTP9	Uncharacterized protein.	Cytochrome c oxidase assembly protein CtaG/Cox11.	0.578
DFL_005029	DFL_007087	A0A437A6W6	A0A436ZUP8	Uncharacterized protein.	Uncharacterized protein.	0.617
DFL_005102	DFL_006345	A0A437A748	A0A437A041	Uncharacterized protein.	Uncharacterized protein.	0.485
DFL_005137	DFL_000690	A0A437A6R6	A0A437AEG6	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Uncharacterized protein.	0.456

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046653

Tetrahydrofolate metabolic process

8 of 33

2.83

9.02

2.97e-18

GO:0006730

One-carbon metabolic process

8 of 54

2.62

8.18

2.62e-17

GO:0019264

Glycine biosynthetic process from serine

6 of 9

3.27

8.07

1.48e-15

GO:0006565

L-serine catabolic process

6 of 9

3.27

8.07

1.48e-15

GO:0046655

Folic acid metabolic process

6 of 11

3.18

7.92

2.29e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

7 of 20

2.99

8.45

1.12e-16

GO:0070905

Serine binding

6 of 9

3.27

8.0

1.96e-15

GO:0004372

Glycine hydroxymethyltransferase activity

6 of 9

3.27

8.0

1.96e-15

GO:0030170

Pyridoxal phosphate binding

6 of 98

2.23

4.62

1.47e-10

GO:0016741

Transferase activity, transferring one-carbon groups

8 of 365

1.79

3.8

1.96e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 558

1.3

0.81

0.0128

GO:0005739

Mitochondrion

5 of 1344

1.02

0.66

0.0128

GO:0005737

Cytoplasm

11 of 10715

0.46

0.35

0.0070

GO:0043231

Intracellular membrane-bounded organelle

10 of 11116

0.4

0.28

0.0404

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35599880

(2022) Glycine max Homologs of DOESNT MAKE INFECTIONS 1, 2, and 3 Function to Impair Heterodera glycines Parasitism While Also Regulating Mitogen Activated Protein Kinase Expression.

6 of 14

3.08

7.22

3.98e-14

PMID:34557481

(2021) Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.

6 of 15

3.05

7.2

3.98e-14

PMID:24957993

(2013) Amino Acid biosynthesis pathways in diatoms.

6 of 127

2.12

3.97

2.31e-09

PMID:35033026

(2022) Transcriptome analysis of Auricularia fibrillifera fruit-body responses to drought stress and rehydration.

2 of 10

2.75

1.26

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8212

Mixed, incl. Glycine metabolic process, and De novo IMP biosynthetic process

10 of 67

2.62

10.34

2.17e-22

CL:8266

De novo IMP biosynthetic process, and Serine hydroxymethyltransferase

8 of 22

3.01

10.16

4.59e-20

CL:8213

Serine family amino acid catabolic process, and De novo IMP biosynthetic process

9 of 50

2.7

9.83

1.28e-20

CL:8268

De novo IMP biosynthetic process

3 of 11

2.88

2.74

9.52e-06

CL:8294

One carbon pool by folate

2 of 5

3.05

1.55

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppp00670

One carbon pool by folate

8 of 22

3.01

10.6

6.04e-21

ppp00460

Cyanoamino acid metabolism

6 of 17

3.0

7.78

2.48e-15

ppp00630

Glyoxylate and dicarboxylate metabolism

7 of 97

2.31

6.09

5.59e-14

ppp00260

Glycine, serine and threonine metabolism

6 of 71

2.37

5.55

2.89e-12

ppp01230

Biosynthesis of amino acids

6 of 258

1.81

3.33

3.01e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196757

Metabolism of folate and pterines

7 of 37

2.72

7.52

2.05e-15

MAP-196849

Metabolism of water-soluble vitamins and cofactors

7 of 177

2.05

4.47

3.32e-11

MAP-196854

Metabolism of vitamins and cofactors

7 of 201

1.99

4.27

5.28e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

4 of 25

2.65

3.94

3.56e-08

MAP-8956320

Nucleotide biosynthesis

4 of 29

2.59

3.83

5.10e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

6 of 15

3.05

7.61

6.33e-15

KW-0663

Pyridoxal phosphate

6 of 64

2.42

5.45

7.60e-12

KW-0808

Transferase

6 of 941

1.25

1.37

3.37e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00464

Serine hydroxymethyltransferase

4 of 7

3.2

4.5

6.46e-09

PF01212

Beta-eliminating lyase

2 of 12

2.67

1.06

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019798

Serine hydroxymethyltransferase, pyridoxal phosphate binding site

6 of 7

3.38

7.86

4.35e-15

IPR039429

Serine hydroxymethyltransferase-like domain

6 of 8

3.32

7.84

4.35e-15

IPR001085

Serine hydroxymethyltransferase

6 of 8

3.32

7.84

4.35e-15

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

6 of 83

2.31

4.57

3.64e-10

IPR015424

Pyridoxal phosphate-dependent transferase

6 of 92

2.26

4.44

5.27e-10

(more ...)

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