DFL_005158 protein (Arthrobotrys flagrans) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

DFL_005158

Uncharacterized protein. (350 aa)

Predicted Functional Partners:

DFL_002217

0.738

DFL_009495

0.702

DFL_002783

0.700

DFL_000992

0.686

DFL_009424

0.676

DFL_000835

0.676

DFL_000820

0.676

DFL_006868

0.673

DFL_005116

0.658

DFL_004040

0.633

Your Current Organism:

Arthrobotrys flagrans

NCBI taxonomy Id: 97331
Other names: A. flagrans, Duddingtonia flagrans, Trichothecium flagrans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFL_000820	DFL_000992	A0A437AFL3	A0A437AFV5	Uncharacterized protein.	Spindle pole body component.	0.940
DFL_000820	DFL_002217	A0A437AFL3	A0A437AAB2	Uncharacterized protein.	Spindle pole body component.	0.926
DFL_000820	DFL_002783	A0A437AFL3	A0A437ABF6	Uncharacterized protein.	Spindle pole body component.	0.929
DFL_000820	DFL_005158	A0A437AFL3	A0A437A7B4	Uncharacterized protein.	Uncharacterized protein.	0.676
DFL_000820	DFL_009495	A0A437AFL3	A0A436ZS45	Uncharacterized protein.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.935
DFL_000835	DFL_000992	A0A437AF08	A0A437AFV5	Spindle pole body component.	Spindle pole body component.	0.982
DFL_000835	DFL_002217	A0A437AF08	A0A437AAB2	Spindle pole body component.	Spindle pole body component.	0.993
DFL_000835	DFL_002783	A0A437AF08	A0A437ABF6	Spindle pole body component.	Spindle pole body component.	0.989
DFL_000835	DFL_005158	A0A437AF08	A0A437A7B4	Spindle pole body component.	Uncharacterized protein.	0.676
DFL_000835	DFL_009424	A0A437AF08	A0A436ZS28	Spindle pole body component.	Spindle pole body component.	0.985
DFL_000835	DFL_009495	A0A437AF08	A0A436ZS45	Spindle pole body component.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.977
DFL_000992	DFL_000820	A0A437AFV5	A0A437AFL3	Spindle pole body component.	Uncharacterized protein.	0.940
DFL_000992	DFL_000835	A0A437AFV5	A0A437AF08	Spindle pole body component.	Spindle pole body component.	0.982
DFL_000992	DFL_002217	A0A437AFV5	A0A437AAB2	Spindle pole body component.	Spindle pole body component.	0.984
DFL_000992	DFL_002783	A0A437AFV5	A0A437ABF6	Spindle pole body component.	Spindle pole body component.	0.985
DFL_000992	DFL_005158	A0A437AFV5	A0A437A7B4	Spindle pole body component.	Uncharacterized protein.	0.686
DFL_000992	DFL_009424	A0A437AFV5	A0A436ZS28	Spindle pole body component.	Spindle pole body component.	0.998
DFL_000992	DFL_009495	A0A437AFV5	A0A436ZS45	Spindle pole body component.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.998
DFL_002217	DFL_000820	A0A437AAB2	A0A437AFL3	Spindle pole body component.	Uncharacterized protein.	0.926
DFL_002217	DFL_000835	A0A437AAB2	A0A437AF08	Spindle pole body component.	Spindle pole body component.	0.993

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

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