DFL_002143 protein (Arthrobotrys flagrans) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

DFL_002143

Aldo_ket_red domain-containing protein. (322 aa)

Predicted Functional Partners:

DFL_001578

0.841

DFL_001092

0.582

DFL_001115

0.582

DFL_009105

0.572

DFL_007480

0.570

DFL_007465

0.565

DFL_004984

0.548

DFL_008244

0.546

DFL_006998

0.522

DFL_007315

0.522

Your Current Organism:

Arthrobotrys flagrans

NCBI taxonomy Id: 97331
Other names: A. flagrans, Duddingtonia flagrans, Trichothecium flagrans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFL_001092	DFL_002143	A0A437AG70	A0A437A9Z8	Ribosomal protein L37; Binds to the 23S rRNA.	Aldo_ket_red domain-containing protein.	0.582
DFL_001115	DFL_002143	A0A437AG96	A0A437A9Z8	Uncharacterized protein.	Aldo_ket_red domain-containing protein.	0.582
DFL_001578	DFL_002143	A0A437A8P1	A0A437A9Z8	Uncharacterized protein.	Aldo_ket_red domain-containing protein.	0.841
DFL_001578	DFL_004984	A0A437A8P1	A0A437A6E3	Uncharacterized protein.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.999
DFL_001578	DFL_007465	A0A437A8P1	A0A436ZWK8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.999
DFL_001578	DFL_007480	A0A437A8P1	A0A436ZVU1	Uncharacterized protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
DFL_001578	DFL_008244	A0A437A8P1	A0A436ZNB3	Uncharacterized protein.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.999
DFL_001578	DFL_009105	A0A437A8P1	A0A436ZQQ2	Uncharacterized protein.	PLD phosphodiesterase domain-containing protein.	0.999
DFL_002143	DFL_001092	A0A437A9Z8	A0A437AG70	Aldo_ket_red domain-containing protein.	Ribosomal protein L37; Binds to the 23S rRNA.	0.582
DFL_002143	DFL_001115	A0A437A9Z8	A0A437AG96	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.582
DFL_002143	DFL_001578	A0A437A9Z8	A0A437A8P1	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.841
DFL_002143	DFL_004984	A0A437A9Z8	A0A437A6E3	Aldo_ket_red domain-containing protein.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.548
DFL_002143	DFL_006998	A0A437A9Z8	A0A436ZV22	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the DapA family.	0.522
DFL_002143	DFL_007315	A0A437A9Z8	A0A436ZVY1	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.522
DFL_002143	DFL_007465	A0A437A9Z8	A0A436ZWK8	Aldo_ket_red domain-containing protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.565
DFL_002143	DFL_007480	A0A437A9Z8	A0A436ZVU1	Aldo_ket_red domain-containing protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.570
DFL_002143	DFL_008244	A0A437A9Z8	A0A436ZNB3	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.546
DFL_002143	DFL_009105	A0A437A9Z8	A0A436ZQQ2	Aldo_ket_red domain-containing protein.	PLD phosphodiesterase domain-containing protein.	0.572
DFL_004984	DFL_001578	A0A437A6E3	A0A437A8P1	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	Uncharacterized protein.	0.999
DFL_004984	DFL_002143	A0A437A6E3	A0A437A9Z8	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	Aldo_ket_red domain-containing protein.	0.548

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.864

expected number of edges:

11

PPI enrichment p-value:

8.6e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006606

Protein import into nucleus

4 of 34

2.26

2.61

7.67e-06

GO:0006913

Nucleocytoplasmic transport

5 of 86

1.96

2.45

5.86e-06

GO:0031053

Primary miRNA processing

2 of 6

2.71

1.49

0.0019

GO:0051168

Nuclear export

3 of 52

1.95

1.47

0.0012

GO:0046907

Intracellular transport

6 of 440

1.33

1.41

7.16e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140142

Nucleocytoplasmic carrier activity

3 of 20

2.37

1.73

0.00057

GO:0000339

RNA cap binding

2 of 6

2.71

1.23

0.0057

GO:0061608

Nuclear import signal receptor activity

2 of 11

2.45

1.09

0.0101

GO:0008139

Nuclear localization sequence binding

2 of 10

2.49

1.09

0.0101

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0005845

mRNA cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0000808

Origin recognition complex

2 of 5

2.79

1.59

0.0013

GO:0005634

Nucleus

10 of 2571

0.78

0.72

4.14e-05

GO:0005694

Chromosome

3 of 263

1.25

0.6

0.0443

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4425

Nuclear localization sequence binding, and CAS/CSE protein, C-terminus

3 of 6

2.89

2.69

1.19e-05

CL:4287

Mixed, incl. Nuclear Envelope Breakdown, and Nucleocytoplasmic carrier activity

5 of 80

1.99

2.62

2.63e-06

CL:9082

mRNA cap binding complex, and Initiation factor 4G

2 of 5

2.79

1.36

0.0034

CL:6807

CDC6 association with the ORC:origin complex

2 of 6

2.71

1.33

0.0038

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

5 of 207

1.57

1.88

1.71e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68616

Assembly of the ORC complex at the origin of replication

3 of 16

2.46

2.03

0.00016

MAP-68867

Assembly of the pre-replicative complex

3 of 47

2.0

1.57

0.00081

MAP-68689

CDC6 association with the ORC:origin complex

2 of 7

2.65

1.44

0.0023

MAP-69278

Cell Cycle, Mitotic

5 of 316

1.39

1.3

0.00040

MAP-69002

DNA Replication Pre-Initiation

3 of 78

1.78

1.29

0.0023

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.01

1.34

0.0038

GOCC:0005664

Nuclear origin of replication recognition complex

2 of 5

2.79

1.32

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 321

1.29

0.86

0.0084

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016024

Armadillo-type fold

4 of 238

1.42

0.64

0.0447

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00913

Importin-beta N-terminal domain

2 of 10

2.49

1.12

0.0090

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