STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IST1IST1 homolog isoform X2. (364 aa)    
Predicted Functional Partners:
SPAST
Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]
    
 0.989
LOC101320609
Charged multivesicular body protein 1b-2-like isoform X5.
    
 
 0.989
VPS4A
Vacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family.
   
 0.984
VPS4B
Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family.
   
 0.970
CHMP5
Charged multivesicular body protein 5.
    
 
 0.964
CHMP2A
Charged multivesicular body protein 2a isoform X2.
    
 0.961
VTA1
Vacuolar protein sorting-associated protein VTA1 homolog isoform X1.
   
 
 0.957
CHMP4C
Charged multivesicular body protein 4c.
    
 0.955
CHMP3
Charged multivesicular body protein 3 isoform X1.
    
 0.950
SPART
Spartin isoform X1.
    
 
 0.931
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.