node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MED1 | NCOA1 | ENSTTRP00000008003 | ENSTTRP00000014337 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.721 |
MED1 | NCOA2 | ENSTTRP00000008003 | ENSTTRP00000012347 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.611 |
MED1 | NCOA3 | ENSTTRP00000008003 | ENSTTRP00000000019 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.925 |
MED1 | NCOR1 | ENSTTRP00000008003 | ENSTTRP00000001899 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 1 isoform X5. | 0.597 |
MED1 | PPARA | ENSTTRP00000008003 | ENSTTRP00000003892 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor alpha. | 0.913 |
MED1 | PPARG | ENSTTRP00000008003 | ENSTTRP00000015704 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.973 |
MED1 | RARB | ENSTTRP00000008003 | ENSTTRP00000010329 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor beta. | 0.782 |
MED1 | RARG | ENSTTRP00000008003 | ENSTTRP00000002606 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor beta. | 0.782 |
MED1 | RXRG | ENSTTRP00000008003 | ENSTTRP00000003428 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-gamma isoform X1. | 0.952 |
MED1 | THRB | ENSTTRP00000008003 | ENSTTRP00000001749 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Thyroid hormone receptor beta isoform X3. | 0.925 |
NCOA1 | MED1 | ENSTTRP00000014337 | ENSTTRP00000008003 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.721 |
NCOA1 | NCOA2 | ENSTTRP00000014337 | ENSTTRP00000012347 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.992 |
NCOA1 | NCOA3 | ENSTTRP00000014337 | ENSTTRP00000000019 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.956 |
NCOA1 | NCOR1 | ENSTTRP00000014337 | ENSTTRP00000001899 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1 isoform X5. | 0.780 |
NCOA1 | PPARA | ENSTTRP00000014337 | ENSTTRP00000003892 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor alpha. | 0.965 |
NCOA1 | PPARG | ENSTTRP00000014337 | ENSTTRP00000015704 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.969 |
NCOA1 | RARB | ENSTTRP00000014337 | ENSTTRP00000010329 | Nuclear receptor coactivator. | Retinoic acid receptor beta. | 0.675 |
NCOA1 | RARG | ENSTTRP00000014337 | ENSTTRP00000002606 | Nuclear receptor coactivator. | Retinoic acid receptor beta. | 0.675 |
NCOA1 | RXRG | ENSTTRP00000014337 | ENSTTRP00000003428 | Nuclear receptor coactivator. | Retinoic acid receptor RXR-gamma isoform X1. | 0.969 |
NCOA1 | THRB | ENSTTRP00000014337 | ENSTTRP00000001749 | Nuclear receptor coactivator. | Thyroid hormone receptor beta isoform X3. | 0.967 |