STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPG5Ectopic P granules protein 5 homolog. (2577 aa)    
Predicted Functional Partners:
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
  
  
 0.802
TECPR2
Tectonin beta-propeller repeat-containing protein 2 isoform X2.
   
  
 0.799
FAT1
Protocadherin Fat 1 isoform X2.
      
 0.796
ENSTTRP00000011017
annotation not available
      
 0.788
PLEKHM1
Pleckstrin homology and RUN domain containing M1.
   
  
 0.744
PSTPIP2
Proline-serine-threonine phosphatase-interacting protein 2 isoform X1.
 
    
 0.697
RILP
Rab-interacting lysosomal protein.
      
 0.691
ATG2B
Autophagy-related protein 2 homolog B isoform X5.
   
  
 0.622
SYNE1
Nesprin-1 isoform X1.
      
 0.601
VPS39
vam6/Vps39-like protein isoform X1.
   
  
 0.591
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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