STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (853 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.990
ENSTTRP00000015457
annotation not available
     
 0.934
CTNNB1
Catenin beta-1.
    
 0.928
TSC2
Tuberin.
    
 0.927
NFX1
Transcriptional repressor NF-X1 isoform X2.
     
 0.921
PSMD4
26S proteasome non-ATPase regulatory subunit 4 isoform X1.
    
 
 0.917
DLG1
Disks large homolog 1 isoform X3; Belongs to the MAGUK family.
    
 0.910
DLG2
Disks large homolog 2 isoform X2.
    
 0.910
TSC1
Hamartin isoform X1.
    
 0.907
DLG3
Discs large MAGUK scaffold protein 3.
    
 0.898
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.