node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP11A1 | CYP17A1 | ENSTTRP00000007543 | ENSTTRP00000011973 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 0.951 |
CYP11A1 | CYP21A2 | ENSTTRP00000007543 | ENSTTRP00000005627 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450 family 21 subfamily A member 2. | 0.927 |
CYP11A1 | CYP7B1 | ENSTTRP00000007543 | ENSTTRP00000001734 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. | 0.965 |
CYP11A1 | DHCR7 | ENSTTRP00000007543 | ENSTTRP00000005463 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 7-dehydrocholesterol reductase isoform X1. | 0.911 |
CYP11A1 | FDX1 | ENSTTRP00000007543 | ENSTTRP00000010706 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Adrenodoxin, mitochondrial. | 0.912 |
CYP11A1 | FDXR | ENSTTRP00000007543 | ENSTTRP00000002448 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Ferredoxin reductase. | 0.990 |
CYP11A1 | LHCGR | ENSTTRP00000007543 | ENSTTRP00000003243 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.959 |
CYP11A1 | LOC101319007 | ENSTTRP00000007543 | ENSTTRP00000015403 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. | 0.986 |
CYP11A1 | STAR | ENSTTRP00000007543 | ENSTTRP00000004220 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroidogenic acute regulatory protein, mitochondrial. | 0.945 |
CYP11A1 | SULT2B1 | ENSTTRP00000007543 | ENSTTRP00000007732 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Sulfotransferase family 2B member 1. | 0.922 |
CYP17A1 | CYP11A1 | ENSTTRP00000011973 | ENSTTRP00000007543 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.951 |
CYP17A1 | CYP21A2 | ENSTTRP00000011973 | ENSTTRP00000005627 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Cytochrome P450 family 21 subfamily A member 2. | 0.897 |
CYP17A1 | CYP7B1 | ENSTTRP00000011973 | ENSTTRP00000001734 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. | 0.927 |
CYP17A1 | DHCR7 | ENSTTRP00000011973 | ENSTTRP00000005463 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 7-dehydrocholesterol reductase isoform X1. | 0.494 |
CYP17A1 | FDX1 | ENSTTRP00000011973 | ENSTTRP00000010706 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Adrenodoxin, mitochondrial. | 0.619 |
CYP17A1 | FDXR | ENSTTRP00000011973 | ENSTTRP00000002448 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Ferredoxin reductase. | 0.476 |
CYP17A1 | LHCGR | ENSTTRP00000011973 | ENSTTRP00000003243 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.979 |
CYP17A1 | LOC101319007 | ENSTTRP00000011973 | ENSTTRP00000015403 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. | 0.979 |
CYP17A1 | STAR | ENSTTRP00000011973 | ENSTTRP00000004220 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Steroidogenic acute regulatory protein, mitochondrial. | 0.791 |
CYP17A1 | SULT2B1 | ENSTTRP00000011973 | ENSTTRP00000007732 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Sulfotransferase family 2B member 1. | 0.936 |