node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLM | FANCM | ENSTTRP00000015530 | ENSTTRP00000006317 | Bloom syndrome protein isoform X1. | Fanconi anemia group M protein isoform X1. | 0.999 |
BLM | RMI1 | ENSTTRP00000015530 | ENSTTRP00000015830 | Bloom syndrome protein isoform X1. | recQ-mediated genome instability protein 1 isoform X1. | 0.998 |
BLM | RMI2 | ENSTTRP00000015530 | ENSTTRP00000004509 | Bloom syndrome protein isoform X1. | recQ-mediated genome instability protein 2. | 0.992 |
BLM | RPA1 | ENSTTRP00000015530 | ENSTTRP00000001099 | Bloom syndrome protein isoform X1. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.994 |
BLM | RPA2 | ENSTTRP00000015530 | ENSTTRP00000007100 | Bloom syndrome protein isoform X1. | Replication protein A 32 kDa subunit. | 0.960 |
BLM | RPA3 | ENSTTRP00000015530 | ENSTTRP00000012930 | Bloom syndrome protein isoform X1. | Replication protein A 14 kDa subunit. | 0.991 |
BLM | TDRD3 | ENSTTRP00000015530 | ENSTTRP00000009552 | Bloom syndrome protein isoform X1. | Tudor domain-containing protein 3 isoform X1. | 0.851 |
BLM | TOP3A | ENSTTRP00000015530 | ENSTTRP00000007726 | Bloom syndrome protein isoform X1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.998 |
BLM | WRN | ENSTTRP00000015530 | ENSTTRP00000011670 | Bloom syndrome protein isoform X1. | Werner syndrome ATP-dependent helicase isoform X2. | 0.756 |
FANCM | BLM | ENSTTRP00000006317 | ENSTTRP00000015530 | Fanconi anemia group M protein isoform X1. | Bloom syndrome protein isoform X1. | 0.999 |
FANCM | RECQL4 | ENSTTRP00000006317 | ENSTTRP00000009402 | Fanconi anemia group M protein isoform X1. | ATP-dependent DNA helicase Q4. | 0.999 |
FANCM | RMI1 | ENSTTRP00000006317 | ENSTTRP00000015830 | Fanconi anemia group M protein isoform X1. | recQ-mediated genome instability protein 1 isoform X1. | 0.999 |
FANCM | RMI2 | ENSTTRP00000006317 | ENSTTRP00000004509 | Fanconi anemia group M protein isoform X1. | recQ-mediated genome instability protein 2. | 0.999 |
FANCM | RPA1 | ENSTTRP00000006317 | ENSTTRP00000001099 | Fanconi anemia group M protein isoform X1. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
FANCM | RPA2 | ENSTTRP00000006317 | ENSTTRP00000007100 | Fanconi anemia group M protein isoform X1. | Replication protein A 32 kDa subunit. | 0.951 |
FANCM | RPA3 | ENSTTRP00000006317 | ENSTTRP00000012930 | Fanconi anemia group M protein isoform X1. | Replication protein A 14 kDa subunit. | 0.945 |
FANCM | TDRD3 | ENSTTRP00000006317 | ENSTTRP00000009552 | Fanconi anemia group M protein isoform X1. | Tudor domain-containing protein 3 isoform X1. | 0.999 |
FANCM | TOP3A | ENSTTRP00000006317 | ENSTTRP00000007726 | Fanconi anemia group M protein isoform X1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.999 |
FANCM | WRN | ENSTTRP00000006317 | ENSTTRP00000011670 | Fanconi anemia group M protein isoform X1. | Werner syndrome ATP-dependent helicase isoform X2. | 0.999 |
RECQL4 | FANCM | ENSTTRP00000009402 | ENSTTRP00000006317 | ATP-dependent DNA helicase Q4. | Fanconi anemia group M protein isoform X1. | 0.999 |