STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOSBProtein fosB isoform X1. (341 aa)    
Predicted Functional Partners:
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
   
 0.999
JUN
Transcription factor AP-1; Belongs to the bZIP family.
   
 0.999
FOS
Proto-oncogene c-Fos.
   
0.993
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
   
0.979
FOSL2
Fos-related antigen 2 isoform X5.
   
0.970
FOSL1
Fos-related antigen 1.
     
0.945
EGR1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.933
HDAC1
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
    
 0.917
HDAC2
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
    
 0.916
MAPK8
Mitogen-activated protein kinase.
    
 0.906
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.