node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERCC1 | ERCC4 | ENSTTRP00000007874 | ENSTTRP00000008876 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA repair endonuclease XPF. | 0.999 |
ERCC1 | FAAP24 | ENSTTRP00000007874 | ENSTTRP00000011587 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Fanconi anemia core complex-associated protein 24 isoform X1. | 0.859 |
ERCC1 | FANCC | ENSTTRP00000007874 | ENSTTRP00000005822 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.782 |
ERCC1 | FANCF | ENSTTRP00000007874 | ENSTTRP00000000844 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Fanconi anemia group F protein. | 0.862 |
ERCC1 | FANCL | ENSTTRP00000007874 | ENSTTRP00000001031 | ERCC excision repair 1, endonuclease non-catalytic subunit. | E3 ubiquitin-protein ligase FANCL isoform X1. | 0.952 |
ERCC1 | MUS81 | ENSTTRP00000007874 | ENSTTRP00000016053 | ERCC excision repair 1, endonuclease non-catalytic subunit. | MUS81 structure-specific endonuclease subunit. | 0.956 |
ERCC1 | RPA1 | ENSTTRP00000007874 | ENSTTRP00000001099 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.772 |
ERCC1 | SLX4 | ENSTTRP00000007874 | ENSTTRP00000016105 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Structure-specific endonuclease subunit SLX4. | 0.974 |
ERCC1 | TOP3A | ENSTTRP00000007874 | ENSTTRP00000007726 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.493 |
ERCC1 | XPA | ENSTTRP00000007874 | ENSTTRP00000000477 | ERCC excision repair 1, endonuclease non-catalytic subunit. | DNA repair protein complementing XP-A cells. | 0.990 |
ERCC4 | ERCC1 | ENSTTRP00000008876 | ENSTTRP00000007874 | DNA repair endonuclease XPF. | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.999 |
ERCC4 | FAAP24 | ENSTTRP00000008876 | ENSTTRP00000011587 | DNA repair endonuclease XPF. | Fanconi anemia core complex-associated protein 24 isoform X1. | 0.965 |
ERCC4 | FANCC | ENSTTRP00000008876 | ENSTTRP00000005822 | DNA repair endonuclease XPF. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.948 |
ERCC4 | FANCF | ENSTTRP00000008876 | ENSTTRP00000000844 | DNA repair endonuclease XPF. | Fanconi anemia group F protein. | 0.965 |
ERCC4 | FANCL | ENSTTRP00000008876 | ENSTTRP00000001031 | DNA repair endonuclease XPF. | E3 ubiquitin-protein ligase FANCL isoform X1. | 0.944 |
ERCC4 | MUS81 | ENSTTRP00000008876 | ENSTTRP00000016053 | DNA repair endonuclease XPF. | MUS81 structure-specific endonuclease subunit. | 0.951 |
ERCC4 | RPA1 | ENSTTRP00000008876 | ENSTTRP00000001099 | DNA repair endonuclease XPF. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.942 |
ERCC4 | SLX4 | ENSTTRP00000008876 | ENSTTRP00000016105 | DNA repair endonuclease XPF. | Structure-specific endonuclease subunit SLX4. | 0.993 |
ERCC4 | TOP3A | ENSTTRP00000008876 | ENSTTRP00000007726 | DNA repair endonuclease XPF. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.951 |
ERCC4 | XPA | ENSTTRP00000008876 | ENSTTRP00000000477 | DNA repair endonuclease XPF. | DNA repair protein complementing XP-A cells. | 0.990 |