STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPS15Epidermal growth factor receptor substrate 15 isoform X2. (891 aa)    
Predicted Functional Partners:
ITSN2
Intersectin-2 isoform X1.
   
0.999
ITSN1
Intersectin-1 isoform X1.
   
0.988
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
    
 0.987
EPN1
Epsin-1-like.
   
 0.986
EPN2
Uncharacterized protein LOC101321500.
   
 0.984
EGFR
Receptor protein-tyrosine kinase.
    
 0.980
EPN3
Epsin-3-like.
   
 0.978
WASL
Neural Wiskott-Aldrich syndrome protein.
    
 0.976
STON2
Stonin-2 isoform X1; Belongs to the Stoned B family.
    
 0.975
AP2A1
Adaptor related protein complex 2 subunit alpha 1.
    
 0.964
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.