node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKLE2 | SIRT2 | ENSTTRP00000010100 | ENSTTRP00000011179 | Ankyrin repeat and LEM domain-containing protein 2 isoform X1. | NAD-dependent protein deacetylase sirtuin-2. | 0.961 |
CD38 | NADK | ENSTTRP00000002369 | ENSTTRP00000015346 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | NAD kinase. | 0.921 |
CD38 | NADSYN1 | ENSTTRP00000002369 | ENSTTRP00000005492 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.898 |
CD38 | NAMPT | ENSTTRP00000002369 | ENSTTRP00000011514 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.945 |
CD38 | PNP | ENSTTRP00000002369 | ENSTTRP00000007423 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.905 |
CD38 | SIRT2 | ENSTTRP00000002369 | ENSTTRP00000011179 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | NAD-dependent protein deacetylase sirtuin-2. | 0.904 |
CD38 | SIRT4 | ENSTTRP00000002369 | ENSTTRP00000005343 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.904 |
CD38 | SIRT5 | ENSTTRP00000002369 | ENSTTRP00000007353 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.897 |
CD38 | SIRT6 | ENSTTRP00000002369 | ENSTTRP00000001595 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | NAD-dependent protein deacetylase sirtuin-6 isoform X5. | 0.907 |
NADK | CD38 | ENSTTRP00000015346 | ENSTTRP00000002369 | NAD kinase. | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | 0.921 |
NADK | NADSYN1 | ENSTTRP00000015346 | ENSTTRP00000005492 | NAD kinase. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.963 |
NADK | NAMPT | ENSTTRP00000015346 | ENSTTRP00000011514 | NAD kinase. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.505 |
NADK | NUDT12 | ENSTTRP00000015346 | ENSTTRP00000000998 | NAD kinase. | Peroxisomal NADH pyrophosphatase NUDT12. | 0.904 |
NADK | SIRT2 | ENSTTRP00000015346 | ENSTTRP00000011179 | NAD kinase. | NAD-dependent protein deacetylase sirtuin-2. | 0.915 |
NADK | SIRT4 | ENSTTRP00000015346 | ENSTTRP00000005343 | NAD kinase. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.915 |
NADK | SIRT5 | ENSTTRP00000015346 | ENSTTRP00000007353 | NAD kinase. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.914 |
NADK | SIRT6 | ENSTTRP00000015346 | ENSTTRP00000001595 | NAD kinase. | NAD-dependent protein deacetylase sirtuin-6 isoform X5. | 0.915 |
NADSYN1 | CD38 | ENSTTRP00000005492 | ENSTTRP00000002369 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. | 0.898 |
NADSYN1 | NADK | ENSTTRP00000005492 | ENSTTRP00000015346 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD kinase. | 0.963 |
NADSYN1 | NAMPT | ENSTTRP00000005492 | ENSTTRP00000011514 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.604 |