STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101322612Uncharacterized protein LOC109551478; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)    
Predicted Functional Partners:
KDM6A
Lysine-specific demethylase 6A isoform X4.
   
 0.895
KDM6B
Dynein heavy chain 2, axonemal.
   
 0.895
ASF1A
Histone chaperone ASF1A isoform X2.
   
 
 0.830
HAT1
Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.
    
 0.829
WDR5
WD repeat-containing protein 5B.
   
 0.802
SETD2
Histone-lysine N-methyltransferase SETD2.
    
 0.794
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2.
    
 0.784
RBBP7
Histone-binding protein RBBP7 isoform X1.
   
 0.781
H2BU1
Histone H2B; Belongs to the histone H2B family.
 
 
 0.777
NASP
Nuclear autoantigenic sperm protein isoform X4.
   
 
 0.774
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.