ABHD16A protein (Tursiops truncatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

ABHD16A

Abhydrolase domain containing 16A. (601 aa)

Predicted Functional Partners:

ABHD6

0.806

LYPLA1

0.792

ABHD11

0.786

PISD

0.772

PTDSS1

0.757

ABHD12

0.709

FAAH

0.706

ENSTTRP00000013375

0.697

PREP

0.694

ABHD3

0.687

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD11	ABHD12	ENSTTRP00000007952	ENSTTRP00000001541	Abhydrolase domain containing 11.	Monoacylglycerol lipase ABHD12 isoform X1.	0.560
ABHD11	ABHD16A	ENSTTRP00000007952	ENSTTRP00000013376	Abhydrolase domain containing 11.	Abhydrolase domain containing 16A.	0.786
ABHD11	ABHD3	ENSTTRP00000007952	ENSTTRP00000002482	Abhydrolase domain containing 11.	Phospholipase ABHD3.	0.690
ABHD11	ABHD6	ENSTTRP00000007952	ENSTTRP00000014584	Abhydrolase domain containing 11.	Monoacylglycerol lipase ABHD6.	0.696
ABHD11	FAAH	ENSTTRP00000007952	ENSTTRP00000008886	Abhydrolase domain containing 11.	Fatty acid amide hydrolase.	0.565
ABHD11	LYPLA1	ENSTTRP00000007952	ENSTTRP00000011221	Abhydrolase domain containing 11.	Acyl-protein thioesterase 1 isoform X1.	0.783
ABHD11	PREP	ENSTTRP00000007952	ENSTTRP00000015975	Abhydrolase domain containing 11.	Prolyl endopeptidase.	0.689
ABHD12	ABHD11	ENSTTRP00000001541	ENSTTRP00000007952	Monoacylglycerol lipase ABHD12 isoform X1.	Abhydrolase domain containing 11.	0.560
ABHD12	ABHD16A	ENSTTRP00000001541	ENSTTRP00000013376	Monoacylglycerol lipase ABHD12 isoform X1.	Abhydrolase domain containing 16A.	0.709
ABHD12	ABHD3	ENSTTRP00000001541	ENSTTRP00000002482	Monoacylglycerol lipase ABHD12 isoform X1.	Phospholipase ABHD3.	0.418
ABHD12	ABHD6	ENSTTRP00000001541	ENSTTRP00000014584	Monoacylglycerol lipase ABHD12 isoform X1.	Monoacylglycerol lipase ABHD6.	0.786
ABHD12	FAAH	ENSTTRP00000001541	ENSTTRP00000008886	Monoacylglycerol lipase ABHD12 isoform X1.	Fatty acid amide hydrolase.	0.712
ABHD12	LYPLA1	ENSTTRP00000001541	ENSTTRP00000011221	Monoacylglycerol lipase ABHD12 isoform X1.	Acyl-protein thioesterase 1 isoform X1.	0.784
ABHD12	PISD	ENSTTRP00000001541	ENSTTRP00000009768	Monoacylglycerol lipase ABHD12 isoform X1.	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.	0.521
ABHD12	PTDSS1	ENSTTRP00000001541	ENSTTRP00000006955	Monoacylglycerol lipase ABHD12 isoform X1.	Phosphatidylserine synthase 1 isoform X5.	0.495
ABHD16A	ABHD11	ENSTTRP00000013376	ENSTTRP00000007952	Abhydrolase domain containing 16A.	Abhydrolase domain containing 11.	0.786
ABHD16A	ABHD12	ENSTTRP00000013376	ENSTTRP00000001541	Abhydrolase domain containing 16A.	Monoacylglycerol lipase ABHD12 isoform X1.	0.709
ABHD16A	ABHD3	ENSTTRP00000013376	ENSTTRP00000002482	Abhydrolase domain containing 16A.	Phospholipase ABHD3.	0.687
ABHD16A	ABHD6	ENSTTRP00000013376	ENSTTRP00000014584	Abhydrolase domain containing 16A.	Monoacylglycerol lipase ABHD6.	0.806
ABHD16A	ENSTTRP00000013375	ENSTTRP00000013376	ENSTTRP00000013375	Abhydrolase domain containing 16A.	annotation not available	0.697

page 1 of 4

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.386

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

8 of 150

1.72

3.19

1.09e-09

GO:0006633

Fatty acid biosynthetic process

6 of 75

1.89

2.98

1.27e-07

GO:0045471

Response to ethanol

3 of 5

2.77

2.58

1.82e-05

GO:0006636

Unsaturated fatty acid biosynthetic process

3 of 7

2.62

2.42

3.19e-05

GO:0000001

Mitochondrion inheritance

3 of 13

2.35

2.12

9.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004768

stearoyl-CoA 9-desaturase activity

3 of 4

2.86

2.38

4.47e-05

GO:0004312

Fatty acid synthase activity

3 of 37

1.9

1.27

0.0031

GO:0016491

Oxidoreductase activity

7 of 1415

0.68

0.39

0.0460

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

3 of 55

1.72

0.86

0.0202

GO:0005737

Cytoplasm

11 of 4644

0.36

0.27

0.0289

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10250

Mixed, incl. Thioesterase, and Pigmentation

3 of 7

2.62

2.02

0.00019

CL:11013

Fatty acid metabolism, and Very long-chain fatty acid biosynthetic process

3 of 12

2.39

1.84

0.00036

CL:11230

Acyltransferase ChoActase/COT/CPT, and acyl-CoA oxidase activity

2 of 5

2.59

1.34

0.0035

CL:11025

Fatty acid desaturase type 1, conserved site, and Fatty acid elongase activity

2 of 6

2.51

1.31

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01212

Fatty acid metabolism

6 of 152

1.58

2.27

6.14e-07

map00061

Fatty acid biosynthesis

3 of 43

1.83

1.48

0.00090

map01040

Biosynthesis of unsaturated fatty acids

3 of 94

1.49

1.05

0.0044

map01100

Metabolic pathways

10 of 3422

0.45

0.35

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8978868

Fatty acid metabolism

7 of 278

1.39

1.79

2.50e-06

MAP-75105

Fatty acyl-CoA biosynthesis

4 of 101

1.59

1.36

0.00086

MAP-556833

Metabolism of lipids

8 of 752

1.01

1.03

3.98e-05

MAP-1430728

Metabolism

9 of 2319

0.58

0.41

0.0090

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

2 of 10

2.29

0.98

0.0152

KW-0249

Electron transport

2 of 18

2.03

0.96

0.0152

KW-0349

Heme

3 of 116

1.4

0.82

0.0152

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00487

Fatty acid desaturase

3 of 10

2.47

1.94

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015876

Acyl-CoA desaturase

3 of 4

2.86

2.24

8.30e-05

IPR005804

Fatty acid desaturase domain

3 of 10

2.47

1.86

0.00034

IPR018506

Cytochrome b5, heme-binding site

3 of 14

2.32

1.74

0.00053

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

3 of 26

2.05

1.39

0.0021

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 27

2.03

1.38

0.0021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 27

2.03

1.52

0.0011

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