STAM2 protein (Tursiops truncatus) - STRING interaction network

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Score

STAM2

Signal transducing adapter molecule 2 isoform X1. (526 aa)

Predicted Functional Partners:

HGS

0.998

USP8

0.985

STAMBP

0.981

STAM

0.969

ITSN2

0.958

RPS27A

0.945

JAK3

0.941

JAK2

0.931

PTPN23

0.927

TSG101

0.926

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HGS	ITSN2	ENSTTRP00000007198	ENSTTRP00000012747	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Intersectin-2 isoform X1.	0.957
HGS	PTPN23	ENSTTRP00000007198	ENSTTRP00000002133	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Tyrosine-protein phosphatase non-receptor type 23.	0.733
HGS	RPS27A	ENSTTRP00000007198	ENSTTRP00000013220	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ubiquitin-40S ribosomal protein S27a.	0.956
HGS	STAM	ENSTTRP00000007198	ENSTTRP00000011441	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 1 isoform X1.	0.999
HGS	STAM2	ENSTTRP00000007198	ENSTTRP00000014767	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 2 isoform X1.	0.998
HGS	TSG101	ENSTTRP00000007198	ENSTTRP00000013050	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Tumor susceptibility 101.	0.993
HGS	USP8	ENSTTRP00000007198	ENSTTRP00000015931	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family.	0.973
ITSN2	HGS	ENSTTRP00000012747	ENSTTRP00000007198	Intersectin-2 isoform X1.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.957
ITSN2	JAK2	ENSTTRP00000012747	ENSTTRP00000010974	Intersectin-2 isoform X1.	Tyrosine-protein kinase.	0.616
ITSN2	JAK3	ENSTTRP00000012747	ENSTTRP00000007331	Intersectin-2 isoform X1.	Tyrosine-protein kinase JAK3.	0.616
ITSN2	RPS27A	ENSTTRP00000012747	ENSTTRP00000013220	Intersectin-2 isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.642
ITSN2	STAM	ENSTTRP00000012747	ENSTTRP00000011441	Intersectin-2 isoform X1.	Signal transducing adapter molecule 1 isoform X1.	0.958
ITSN2	STAM2	ENSTTRP00000012747	ENSTTRP00000014767	Intersectin-2 isoform X1.	Signal transducing adapter molecule 2 isoform X1.	0.958
JAK2	ITSN2	ENSTTRP00000010974	ENSTTRP00000012747	Tyrosine-protein kinase.	Intersectin-2 isoform X1.	0.616
JAK2	JAK3	ENSTTRP00000010974	ENSTTRP00000007331	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK3.	0.927
JAK2	RPS27A	ENSTTRP00000010974	ENSTTRP00000013220	Tyrosine-protein kinase.	ubiquitin-40S ribosomal protein S27a.	0.596
JAK2	STAM	ENSTTRP00000010974	ENSTTRP00000011441	Tyrosine-protein kinase.	Signal transducing adapter molecule 1 isoform X1.	0.920
JAK2	STAM2	ENSTTRP00000010974	ENSTTRP00000014767	Tyrosine-protein kinase.	Signal transducing adapter molecule 2 isoform X1.	0.931
JAK3	ITSN2	ENSTTRP00000007331	ENSTTRP00000012747	Tyrosine-protein kinase JAK3.	Intersectin-2 isoform X1.	0.616
JAK3	JAK2	ENSTTRP00000007331	ENSTTRP00000010974	Tyrosine-protein kinase JAK3.	Tyrosine-protein kinase.	0.927