STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HEPHHephaestin isoform X2; Belongs to the multicopper oxidase family. (1158 aa)    
Predicted Functional Partners:
SLC40A1
Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
    
 0.990
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
 
 0.926
HMOX2
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
    
 0.918
FXN
Frataxin, mitochondrial.
     
 0.914
HMOX1
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
    
 0.905
CP
Ceruloplasmin isoform X2; Belongs to the multicopper oxidase family.
  
  
 
0.901
SLC11A2
Natural resistance-associated macrophage protein 2 isoform X1.
  
 
 0.779
MFGE8
Lactadherin.
 
  
 0.759
EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1.
 
  
 0.724
HFE
Hereditary hemochromatosis protein; Belongs to the MHC class I family.
      
 0.656
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.